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1
Clinical outcomes of laparoscopic cholecystectomy in elderly patients after preoperative assessment and optimization of comorbidities.老年患者术前评估及合并症优化后腹腔镜胆囊切除术的临床结局
Ann Hepatobiliary Pancreat Surg. 2018 Nov;22(4):374-379. doi: 10.14701/ahbps.2018.22.4.374. Epub 2018 Nov 27.
2
Laparoscopic cholecystectomy for acute cholecystitis: prospective trial.腹腔镜胆囊切除术治疗急性胆囊炎:前瞻性试验。
World J Surg. 1997 Jun;21(5):540-5. doi: 10.1007/pl00012283.
3
Early decision for conversion of laparoscopic to open cholecystectomy for treatment of acute cholecystitis.早期决定将腹腔镜胆囊切除术转换为开腹胆囊切除术以治疗急性胆囊炎。
Am J Surg. 1997 Jun;173(6):513-7. doi: 10.1016/s0002-9610(97)00005-6.
4
Role of laparoscopic cholecystectomy in the management of gangrenous cholecystitis.腹腔镜胆囊切除术在坏疽性胆囊炎治疗中的作用
Am J Surg. 2001 Jan;181(1):71-5. doi: 10.1016/s0002-9610(00)00525-0.
5
Outcomes of Xanthogranulomatous cholecystitis in laparoscopic era: A retrospective Cohort study.腹腔镜时代黄色肉芽肿性胆囊炎的治疗结果:一项回顾性队列研究。
J Minim Access Surg. 2013 Jul;9(3):109-15. doi: 10.4103/0972-9941.115368.
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Guidelines to laparoscopic management of acute cholecystitis.急性胆囊炎的腹腔镜治疗指南。
Acta Chir Belg. 2000 Sep-Oct;100(5):198-204.
7
Acute cholecystitis in elderly patients: A case for early cholecystectomy.老年患者的急性胆囊炎:早期胆囊切除术的实例
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Laparoscopic cholecystectomy in the elderly.老年人的腹腔镜胆囊切除术
JSLS. 2005 Oct-Dec;9(4):408-10.
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Cholecystitis in the octogenarian: is laparoscopic cholecystectomy the best approach?老年胆囊炎:腹腔镜胆囊切除术是最佳治疗方法吗?
Am Surg. 2001 Jul;67(7):637-40.
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[Laparoscopic cholecystectomy and open cholecystectomy in acute cholecystitis: critical analysis of 520 cases].[急性胆囊炎的腹腔镜胆囊切除术与开腹胆囊切除术:520例病例的批判性分析]
Acta Med Port. 2014 Nov-Dec;27(6):685-91. Epub 2014 Dec 30.

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Emergency cholecystectomy: risk factors and impact of delay on electively booked patients, a 5-year experience of a tertiary care center.急诊胆囊切除术:危险因素及延误对择期手术患者的影响,一家三级医疗中心的5年经验
BMC Surg. 2024 Dec 20;24(1):396. doi: 10.1186/s12893-024-02694-8.
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The Safety of Laparoscopic Cholecystectomy in Super-elderly Patients: A Propensity Score Matching Analysis.超高龄患者腹腔镜胆囊切除术的安全性:倾向评分匹配分析
Cureus. 2023 Jul 18;15(7):e42097. doi: 10.7759/cureus.42097. eCollection 2023 Jul.
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The Safety of Minimally Invasive and Open Cholecystectomy in Elderly Patients With Acute Cholecystitis: A Systematic Review.老年急性胆囊炎患者行微创与开腹胆囊切除术的安全性:一项系统评价
Cureus. 2022 Nov 6;14(11):e31170. doi: 10.7759/cureus.31170. eCollection 2022 Nov.
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Pyogenic Liver Abscess Complicating Acute Cholecystitis: Different Management Options.化脓性肝脓肿合并急性胆囊炎:不同的治疗选择。
Medicina (Kaunas). 2022 Jun 9;58(6):782. doi: 10.3390/medicina58060782.
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Is cholecystectomy safe in extremely elderly patients?胆囊切除术在高龄患者中是否安全?
J Minim Invasive Surg. 2021 Sep 15;24(3):126-127. doi: 10.7602/jmis.2021.24.3.126.
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Safe and feasible outcomes of cholecystectomy in extremely elderly patients (octogenarians vs. nonagenarians).高龄患者(八旬老人与九旬老人)胆囊切除术的安全可行结果。
J Minim Invasive Surg. 2021 Sep 15;24(3):139-144. doi: 10.7602/jmis.2021.24.3.139.
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Safety of Laparoscopic Cholecystectomy for Acute Cholecystitis in the Elderly: A Multivariate Analysis of Risk Factors for Intra and Postoperative Complications.老年急性胆囊炎患者行腹腔镜胆囊切除术的安全性:围手术期并发症危险因素的多因素分析
Medicina (Kaunas). 2021 Mar 2;57(3):230. doi: 10.3390/medicina57030230.
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Effects of dexmedetomidine on cognitive function in elderly patients after laparoscopic cholecystectomy: A protocol for systematic review and meta-analysis.右美托咪定对老年患者腹腔镜胆囊切除术后认知功能的影响:一项系统评价与Meta分析方案
Medicine (Baltimore). 2020 May;99(20):e20177. doi: 10.1097/MD.0000000000020177.
9
HDAC2 hyperexpression alters hippocampal neuronal transcription and microglial activity in neuroinflammation-induced cognitive dysfunction.HDAC2 过度表达改变神经炎症诱导的认知功能障碍中海马神经元转录和小胶质细胞活性。
J Neuroinflammation. 2019 Dec 3;16(1):249. doi: 10.1186/s12974-019-1640-z.

本文引用的文献

1
Evolution in the management of acute cholecystitis in the elderly: population-based cohort study.老年人急性胆囊炎治疗的演变:基于人群的队列研究。
Surg Endosc. 2018 Oct;32(10):4078-4086. doi: 10.1007/s00464-018-6092-5. Epub 2018 Jul 25.
2
Early Cholecystectomy for Acute Cholecystitis in the Elderly Population: A Systematic Review and Meta-Analysis.老年人群急性胆囊炎的早期胆囊切除术:系统评价与荟萃分析
Dig Surg. 2017;34(5):371-379. doi: 10.1159/000455241. Epub 2017 Jan 18.
3
Preoperative risk factors for conversion from laparoscopic to open cholecystectomy: a validated risk score derived from a prospective U.K. database of 8820 patients.腹腔镜胆囊切除术转为开腹胆囊切除术的术前危险因素:一项来自英国8820例患者前瞻性数据库的有效风险评分。
HPB (Oxford). 2016 Nov;18(11):922-928. doi: 10.1016/j.hpb.2016.07.015. Epub 2016 Aug 31.
4
The safety and efficacy of percutaneous transhepatic gallbladder drainage in elderly patients with acute cholecystitis before laparoscopic cholecystectomy.经皮经肝胆管引流术在老年急性胆囊炎患者腹腔镜胆囊切除术术前的安全性和有效性
Ann Surg Treat Res. 2015 Aug;89(2):68-73. doi: 10.4174/astr.2015.89.2.68. Epub 2015 Jul 9.
5
A retrospective comparison of older and younger adults undergoing early laparoscopic cholecystectomy for mild to moderate calculous cholecystitis.对因轻至中度结石性胆囊炎接受早期腹腔镜胆囊切除术的老年人和年轻人进行回顾性比较。
J Am Geriatr Soc. 2015 May;63(5):1010-6. doi: 10.1111/jgs.13330. Epub 2015 May 6.
6
Primary cholecystectomy is feasible in elderly patients with acute cholecystitis.对于患有急性胆囊炎的老年患者,一期胆囊切除术是可行的。
Aging Clin Exp Res. 2015 Dec;27(6):921-6. doi: 10.1007/s40520-015-0361-0. Epub 2015 Apr 24.
7
Clinical outcome for laparoscopic cholecystectomy in extremely elderly patients.极高龄患者腹腔镜胆囊切除术的临床结局
Ann Surg Treat Res. 2015 Mar;88(3):145-51. doi: 10.4174/astr.2015.88.3.145. Epub 2015 Feb 27.
8
Cholecystectomy in octogenarians: be careful.老年患者的胆囊切除术:需谨慎。
Updates Surg. 2014 Dec;66(4):265-8. doi: 10.1007/s13304-014-0267-y. Epub 2014 Sep 30.
9
Management of acute cholecystitis: prevalence of percutaneous cholecystostomy and delayed cholecystectomy in the elderly.急性胆囊炎的治疗:老年人经皮胆囊造口术和延期胆囊切除术的流行情况。
J Gastrointest Surg. 2014 Feb;18(2):328-33. doi: 10.1007/s11605-013-2341-z. Epub 2013 Nov 6.
10
Acute cholecystitis: early versus delayed cholecystectomy, a multicenter randomized trial (ACDC study, NCT00447304).急性胆囊炎:早期与延迟胆囊切除术的多中心随机试验(ACDC 研究,NCT00447304)。
Ann Surg. 2013 Sep;258(3):385-93. doi: 10.1097/SLA.0b013e3182a1599b.

老年患者术前评估及合并症优化后腹腔镜胆囊切除术的临床结局

Clinical outcomes of laparoscopic cholecystectomy in elderly patients after preoperative assessment and optimization of comorbidities.

作者信息

Shin Min Su, Park Sei Hyeog

机构信息

Department of Surgery, National Medical Center, Seoul, Korea.

出版信息

Ann Hepatobiliary Pancreat Surg. 2018 Nov;22(4):374-379. doi: 10.14701/ahbps.2018.22.4.374. Epub 2018 Nov 27.

DOI:10.14701/ahbps.2018.22.4.374
PMID:30588529
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6295375/
Abstract

BACKGROUNDS/AIMS: Early laparoscopic cholecystectomy is considered as the standard treatment of acute cholecystitis. However, whether this procedure is desirable in elderly patients with acute cholecystitis is not clearly elucidated. In this study, we aimed to evaluate the effects of thorough preoperative assessment and consultation for complications on clinical outcomes in elderly patients over 65 and over 80 years.

METHODS

We retrospectively analyzed 205 patients who were diagnosed with acute cholecystitis between January 2010 and April 2018. The patients were assigned to three groups: group A (aged <65 years), group B, (aged between 65 and 79 years), and group C (aged >79 years). Laparoscopic cholecystectomy was performed after preoperative evaluation, such as echocardiography, pulmonary function test, and consultation about past history.

RESULTS

Significant differences were not found in the complication rate among the age groups. Open conversion was required in eight of the 114 patients in group A, seven of the 70 patients in group B, and one of the 21 patients in group C. However, no statistical significance was found. Moreover, no difference was noted in the start of the meal and the period from surgery to last visit, but hospital stay after surgery was longer in groups b and c.

CONCLUSIONS

When sufficient preoperative assessment and treatment were performed, complication and conversion rates were not significantly different among the age groups. In extremely elderly patients, preoperative evaluation and elective laparoscopic cholecystectomy were desirable.

摘要

背景/目的:早期腹腔镜胆囊切除术被视为急性胆囊炎的标准治疗方法。然而,对于老年急性胆囊炎患者是否适合该手术,目前尚不清楚。在本研究中,我们旨在评估对65岁及以上和80岁及以上老年患者进行全面术前评估及并发症咨询对临床结局的影响。

方法

我们回顾性分析了2010年1月至2018年4月期间被诊断为急性胆囊炎的205例患者。患者被分为三组:A组(年龄<65岁)、B组(年龄在65至79岁之间)和C组(年龄>79岁)。在进行超声心动图、肺功能测试等术前评估以及了解既往病史后,实施腹腔镜胆囊切除术。

结果

各年龄组之间的并发症发生率未发现显著差异。A组114例患者中有8例需要转为开腹手术,B组70例患者中有7例,C组21例患者中有1例。然而,未发现统计学意义。此外,在进食开始时间以及从手术到最后一次就诊的时间方面未发现差异,但B组和C组术后住院时间更长。

结论

当进行充分的术前评估和治疗时,各年龄组之间的并发症和中转率无显著差异。对于极高龄患者,术前评估和选择性腹腔镜胆囊切除术是可取的。