Raslan Eman, Soliman Saeed S Abduljalil, Nour Zeinab A, Ahmed Dalia, Saad Nagwa Eid Sobhy
Faculty of Medicine, Cairo University, Giza, Egypt.
High Blood Press Cardiovasc Prev. 2019 Feb;26(1):77-80. doi: 10.1007/s40292-018-0295-7. Epub 2018 Dec 26.
Coronary heart disease is a major cause of death worldwide. Although the relationship between vitamin D status and cardiovascular diseases is not clearly understood, vitamin D deficiency could be a potentially modifiable and underestimated risk factor for ischemic heart diseases. This study aims to assess and compare vitamin D status between patient group with chronic stable angina and matched control group.
A case-control study was conducted on chronic stable angina patients and matched controls attending family medicine/internal medicine clinics at Cairo University Hospitals. Forty two adult patients with chronic stable angina and forty two matched controls were studied. Detailed medical history, examination, and laboratory tests (vitamin D, fasting lipid profile, and blood sugar) were collected from study participants of both groups.
Severe vitamin D deficiency was found in 78.6% and 7.1% of cases and controls, respectively. Vitamin D level was found to be a significant predictor of chronic stable angina. Every unit (ng/ml) increase in vitamin D level decreases the chance of the subject to have chronic stable angina by 0.30 times.
There is a significant association between vitamin D deficiency and the occurrence of chronic stable angina.
冠心病是全球主要的死亡原因。尽管维生素D状态与心血管疾病之间的关系尚未完全明确，但维生素D缺乏可能是缺血性心脏病一个潜在可改变且被低估的危险因素。本研究旨在评估并比较慢性稳定型心绞痛患者组与匹配的对照组之间的维生素D状态。
在开罗大学医院的家庭医学/内科诊所对慢性稳定型心绞痛患者及匹配的对照者进行了一项病例对照研究。研究了42例成年慢性稳定型心绞痛患者和42例匹配的对照者。从两组研究参与者处收集了详细的病史、检查及实验室检查结果（维生素D、空腹血脂谱和血糖）。
病例组和对照组中维生素D严重缺乏者分别占78.6%和7.1%。维生素D水平被发现是慢性稳定型心绞痛的一个显著预测因素。维生素D水平每升高一个单位（纳克/毫升），受试者患慢性稳定型心绞痛的几率就降低0.30倍。
维生素D缺乏与慢性稳定型心绞痛的发生之间存在显著关联。
