Takato T, Harii K, Nakatsuka T, Ohtake T
Department of Plastic Surgery, Faculty of Medicine, University of Tokyo, Japan.
J Reconstr Microsurg. 1988 Oct;4(5):391-7. doi: 10.1055/s-2007-1006949.
The purpose of this study was the sequential evaluation of vascularized bone by quantitative analysis of bone scintigraphy with Tc-99m methylene diphosphonate (MDP). The correlation between the uptake of Tc-99m MDP and the morphologic behavior of vascularized bone was investigated, simultaneously with bone labeling, contact microradiogram (CMR), and histology of an undecalcified sample. In this experiment, 41 adult female rabbits were used. An island tibia pedicled with the popliteal vessels was used as the model of vascularized bone. The maximum uptake of Tc-99m MDP was observed at two to four postoperative weeks. When bone marrow was partially exposed, the uptake was significantly large. On the basis of this experimental study, the degree of Tc-99m MDP uptake seemed to depend primarily on the osteoblastic activity of vascularized bone. The newly-formed bone was observed mainly at periosteal sites.
本研究的目的是通过用锝-99m亚甲基二膦酸盐（MDP）进行骨闪烁显像的定量分析，对带血管骨进行序贯评估。研究了锝-99m MDP摄取与带血管骨形态学行为之间的相关性，同时进行了骨标记、接触微射线照相（CMR）和未脱钙样本的组织学检查。在本实验中，使用了41只成年雌性兔子。以腘血管为蒂的岛状胫骨用作带血管骨模型。术后两到四周观察到锝-99m MDP的最大摄取量。当骨髓部分暴露时，摄取量明显增大。基于本实验研究，锝-99m MDP摄取程度似乎主要取决于带血管骨的成骨细胞活性。新形成的骨主要在骨膜部位观察到。
