Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Korea.
Virus Research and Testing Group, Korea Research Institute of Chemical Technology, Daejeon 34114, Korea.
Mol Cells. 2018 Dec 31;41(12):993-999. doi: 10.14348/molcells.2018.0425. Epub 2018 Dec 10.
One of the most interesting findings from genome-wide expression analysis is that a considerable amount of noncoding RNA (ncRNA) is present in the cell. Recent studies have identified diverse biological functions of ncRNAs, which are expressed in a much wider array of forms than proteins. Certain ncRNAs associated with diseases, in particular, have attracted research attention as novel therapeutic targets and diagnostic markers. BC200 RNA, a 200-nucleotide ncRNA originally identified as a neuron-specific transcript, is abnormally over-expressed in several types of cancer tissue. A number of recent studies have suggested mechanisms by which abnormal expression of BC200 RNA contributes to the development of cancer. In this article, we first provide a brief review of a recent progress in identifying functions of BC200 RNA in cancer cells, and then offer examples of other ncRNAs as new therapeutic targets and diagnostic markers for human cancer. Finally, we discuss future directions of studies on BC200 RNA for new cancer treatments.
全基因组表达分析最有趣的发现之一是，细胞中存在相当数量的非编码 RNA（ncRNA）。最近的研究已经确定了 ncRNA 的多种生物学功能，其表达形式比蛋白质广泛得多。某些与疾病相关的 ncRNA，特别是作为新型治疗靶点和诊断标志物，引起了研究关注。BC200 RNA 是一种最初被鉴定为神经元特异性转录物的 200 个核苷酸 ncRNA，在几种类型的癌症组织中异常过表达。最近的一些研究表明，BC200 RNA 异常表达有助于癌症发展的机制。在本文中，我们首先简要回顾了最近在鉴定 BC200 RNA 在癌细胞中的功能方面的进展，然后提供了其他 ncRNA 作为人类癌症新的治疗靶点和诊断标志物的实例。最后，我们讨论了针对 BC200 RNA 进行新的癌症治疗研究的未来方向。
