Kang Le, Miao Ming-San, Liu Hui-Juan, Li Ning
Henan University of Traditional Chinese Medicine, Zhengzhou 450046, China.
Zhongguo Zhong Yao Za Zhi. 2018 Nov;43(22):4547-4552. doi: 10.19540/j.cnki.cjcmm.20180625.005.
According to the characteristics of gout's clinical symptoms, the common gout animal models were analyzed, and the anastomosis and application prospect of the existing gout animal models with the clinical symptoms were discussed. At present, there are three models of gout: hyperuricemia model, gouty arthritis model and gouty nephropathy model. There are many methods of gout modeling, but there is a lack of animal model replication that could reflect the characteristics of gout's clinical symptoms and reflect the etiology of gout, and there is still a gap between the clinical symptoms and the clinical symptoms. In this paper, the characteristics and modeling methods of the three animal models were summarized, and compared with the clinical symptoms and standards, the anastomosis between the existing animal models and the clinical symptoms were analyzed and discussed, and the evaluation and improvement methods of the corresponding animal models were put forward. It provides a reliable experimental method for the treatment of gout by traditional Chinese medicine.
根据痛风临床症状特点，分析常见痛风动物模型，并探讨现有痛风动物模型与临床症状的吻合度及应用前景。目前有三种痛风模型：高尿酸血症模型、痛风性关节炎模型和痛风性肾病模型。痛风建模方法众多，但缺乏能反映痛风临床症状特点及病因的动物模型复制方法，且与临床症状仍存在差距。本文总结了三种动物模型的特点及建模方法，与临床症状和标准进行对比，分析讨论现有动物模型与临床症状的吻合情况，提出相应动物模型的评价及改进方法。为中医药治疗痛风提供可靠的实验方法。
