Xiang Li-Ling, Miao Ming-San, Wang Can, Zhang Meng-Fei, Fang Xiao-Yan
Henan University of Chinese Medicine, Zhengzhou 450046, China.
Zhongguo Zhong Yao Za Zhi. 2017 Jul;42(14):2824-2828. doi: 10.19540/j.cnki.cjcmm.20170609.009.
Based on the clinical symptom characteristics of transient ischemic attack in Chinese and Western medicines, the existing models of transient ischemic attack were summarized and analyzed. Then the advantages and disadvantages of each model, the diagnostic criteria of traditional Chinese and Western medicine and clinical symptoms compliance were analyzed to put forward the evaluation method and improvement method of the corresponding animal models. It was found that there were many modeling methods of transient ischemic attack, but they can not reflect the transience, reversibility, recurrence and other typical characteristics of the disease, with significant differences with clinical symptoms. Moreover, there is lack of reasonable quantitative criteria for the success of the animal model. By combining the existing single factor animal models, a composite animal model that was more closely related to the clinical symptoms of transient ischemic attack was established to replicate an animal model that was more compatible with the characteristics of clinical symptoms. It is the future development directions of the transient ischemic attack animal models to establish reasonable quantitative standards, reflect the causes of Chinese and Western medicine symptoms and improving a series of systematic and complete model evaluation methods.
基于中西医对短暂性脑缺血发作的临床症状特点，对现有的短暂性脑缺血发作模型进行总结分析。进而分析各模型的优缺点、中西医诊断标准及与临床症状的符合情况，提出相应动物模型的评价方法及改进方法。研究发现，短暂性脑缺血发作的建模方法众多，但均不能体现该病的短暂性、可逆性、复发性等典型特征，与临床症状差异较大。而且动物模型成功缺乏合理的量化标准。通过整合现有的单因素动物模型，建立了与短暂性脑缺血发作临床症状更为贴近的复合动物模型，以复制出更符合临床症状特点的动物模型。建立合理的量化标准、体现中西医症状成因及完善一系列系统完整的模型评价方法是短暂性脑缺血发作动物模型未来的发展方向。
