Tian Shuo, Bai Ming, Miao Ming-San, Kang Le
Henan University of Chinese Medicine, Zhengzhou 450046, China.
Zhongguo Zhong Yao Za Zhi. 2018 Feb;43(4):853-856. doi: 10.19540/j.cnki.cjcmm.20171027.024.
The coincidence of the existing eczema animal model and the clinical characteristics of eczema, and the application characteristics of eczema animal model were analyzed, and the evaluation method and improvement method of corresponding eczema animal model was put forward. Based on the clinical diagnostic criteria of eczema of traditional Chinese medicine and western medicine, the characteristics of current eczema model and the modeling method were summarized, and the anastomosis situations between the existing animal model and the eczema clinical characteristics were analyzed. At present, the back eczema models of mice have been usually used, which reflected the pathophysiological characteristics of clinical eczema to a certain degree. However, the existing animal models fail to reflect the clinical characteristics of traditional Chinese medicine. Future studies focused on establishing animal models that better reflect the clinical characteristics of eczema and the index system of eczema model.
分析了现有湿疹动物模型与湿疹临床特征的契合度以及湿疹动物模型的应用特点，提出了相应湿疹动物模型的评价方法和改进方法。基于中西医湿疹临床诊断标准，总结了当前湿疹模型的特点及建模方法，分析了现有动物模型与湿疹临床特征的吻合情况。目前常用小鼠背部湿疹模型，其在一定程度上反映了临床湿疹的病理生理特征。然而，现有动物模型未能体现中医临床特征。未来研究重点在于建立能更好反映湿疹临床特征的动物模型及湿疹模型指标体系。
