de Luis Daniel Antonio, Izaola Olatz, Primo David, de la Fuente Beatriz, Aller Rocio
Center of Investigation of Endocrinology and Nutrition, Medicine School and Dpt of Endocrinology and Investigation, Hospital Clinico Universitario, University of Valladolid, Valladolid, Spain.
Center of Investigation of Endocrinology and Nutrition, Medicine School and Dpt of Endocrinology and Investigation, Hospital Clinico Universitario, University of Valladolid, Valladolid, Spain.
Endocrinol Diabetes Nutr. 2017 Oct;64(8):440-445. doi: 10.1016/j.endinu.2017.06.001. Epub 2017 Aug 7.
Few studies assessing the relationship between single nucleotide polymorphisms in CNR2 and obesity or its related metabolic parameters are available.
To investigate the influence of polymorphism rs3123554 in the CNR2 receptor gene on obesity anthropometric parameters, insulin resistance, and adipokines in subjects with obesity.
The study population consisted of 1027 obese subjects, who were performed bioelectrical impedance analyses, blood pressure measurements, serial assessments of dietary intake during three days, and biochemical tests.
Genotypes GG, GA, and AA were found in 339 (33.0%), 467 (45.5%), and 221 (21.5%) respectively. Body mass index, weight, fat mass, waist circumference, insulin, HOMA-IR, and triglyceride and leptin levels were higher in A-allele carriers as compared to non A-allele carriers. No differences were seen in these parameters between the GA and AA genotypes. There were no statistical differences in dietary intake.
The main study finding was the association of the minor allele of the SNP rs3123554 in the CNR2 gene with body weight and triglyceride, HOMA-IR, insulin, and leptin levels.
评估CNR2单核苷酸多态性与肥胖或其相关代谢参数之间关系的研究较少。
探讨CNR2受体基因多态性rs3123554对肥胖受试者的肥胖人体测量参数、胰岛素抵抗和脂肪因子的影响。
研究人群包括1027名肥胖受试者，他们接受了生物电阻抗分析、血压测量、三天饮食摄入量的连续评估以及生化检测。
分别发现基因型GG、GA和AA的受试者有339名（33.0%）、467名（45.5%）和221名（21.5%）。与非A等位基因携带者相比，A等位基因携带者的体重指数、体重、脂肪量、腰围、胰岛素、HOMA-IR、甘油三酯和瘦素水平更高。GA和AA基因型在这些参数上没有差异。饮食摄入量没有统计学差异。
主要研究发现是CNR2基因中SNP rs3123554的次要等位基因与体重、甘油三酯、HOMA-IR、胰岛素和瘦素水平相关。
