Department of Family Medicine and Public Health, University of California, 9500 Gilman Drive #0725, La Jolla, San Diego, CA 92093-0725, USA.
Hospital del Mar Institute of Medical Research (IMIM), School of Medicine, Universitat Autonoma de Barcelona, and CIBERESP, Carrer del Dr. Aiguader, 88, E-08003 Barcelona, Catalonia, Spain.
Environ Toxicol Pharmacol. 2019 Feb;66:24-35. doi: 10.1016/j.etap.2018.12.018. Epub 2018 Dec 23.
Some evidence in humans suggests that persistent organic pollutants (POPs), including organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs), may alter the blood lipid composition. This study analyzed associations between serum POPs concentrations in young adulthood with blood lipid levels up to 23 years later.
Serum POPs were measured in year 2 of follow-up (n = 180 men and women, ages: 20-32y), and plasma lipids in follow-up years 2, 7, 10, 15, 20 and 25. 32 POPs were detectable in ≥75% of participants (23 PCBs, 8 OCPs and PBB-153). We created summary scores for PCBs and OCPs for both wet-weight, and lipid standardized (LP) concentrations. We used repeated measures regression adjusting for demographic factors, BMI, smoking, diabetes status, among others.
We observed positive associations of the 23 LP-PCB score with total cholesterol (β [95%CI]: 5.0 mg/dL [0.7, 9.2]), triglycerides (7.8 mg/dL [-0.9, 16.5]), LDL (4.2 mg/dL [0.2, 8.2]), oxidized LDL 3.4 U/L (-0.05, 6.8), and cholesterol/HDL ratio (0.2 [0.02, 0.3]). The associations for triglycerides (14.7 mg/dL [0.4, 20.1]), cholesterol/HDL (0.33 [0.09, 0.56]) and, to some extent, LDL (4.7 md/dL [-1.6, 10.9]) were only observed among participants in the upper 50th percentile of BMI. Non-dioxin-like PCBs had stronger associations that dioxin-like PCBs. OCPs and PBB-s had positive associations with most outcomes.
PCBs and PBB-153 measured in young adulthood were positively associated with prospective alterations in most blood lipid components, with evidence of effect modification by BMI. Further longitudinal studies with multiple measures of POPs overtime are needed.
一些人类研究证据表明，持久性有机污染物（POPs），包括有机氯农药（OCPs）和多氯联苯（PCBs），可能会改变血液中的脂质成分。本研究分析了青年时期血清中 POPs 浓度与 23 年后血液中脂质水平之间的关联。
在随访的第 2 年（n=180 名男性和女性，年龄：20-32 岁）测量血清 POPs 浓度，随后在随访的第 2、7、10、15、20 和 25 年测量血浆脂质。在≥75%的参与者中可检测到 32 种 POPs（23 种 PCB、8 种 OCP 和 PBB-153）。我们为湿重和脂质标准化（LP）浓度的 PCBs 和 OCP 创建了综合评分。我们使用重复测量回归方法，调整了人口统计学因素、BMI、吸烟、糖尿病状态等因素。
我们发现，23 种 LP-PCB 评分与总胆固醇（β[95%CI]：5.0mg/dL[0.7，9.2]）、甘油三酯（7.8mg/dL[-0.9，16.5]）、低密度脂蛋白（4.2mg/dL[0.2，8.2]）、氧化低密度脂蛋白 3.4U/L（-0.05，6.8）和胆固醇/高密度脂蛋白比值（0.2[0.02，0.3]）呈正相关。甘油三酯（14.7mg/dL[0.4，20.1]）、胆固醇/高密度脂蛋白（0.33[0.09，0.56]）和 LDL（4.7md/dL[-1.6，10.9]）的关联仅在 BMI 处于前 50%的参与者中观察到。非二恶英类 PCBs 的关联强于二恶英类 PCBs。OCPs 和 PBB-153 与大多数结果呈正相关。
青年时期测量的 PCBs 和 PBB-153 与大多数血液脂质成分的未来变化呈正相关，BMI 可能是一个影响因素。需要进行更多具有多个时间点的 POPs 测量的纵向研究。
