Epidemiology Branch, National Institute of Environmental Health Sciences, Department of Health and Human Services, National Institutes of Health, 111 TW Alexander Drive, MD A3-05, Research Triangle Park, NC, 27709, USA.
Office of the Director, National Institute of Environmental Health Sciences and the National Toxicology Program, Department of Health and Human Services, National Institutes of Health, Research Triangle Park, NC, USA.
Curr Environ Health Rep. 2020 Mar;7(1):30-47. doi: 10.1007/s40572-020-00265-6.
Although vulnerable populations are disproportionately exposed to synthetic chemicals with endocrine disrupting properties, few recent reviews have summarized the impact of synthetic chemicals on cardiometabolic health among these groups.
Of 37 eligible epidemiological studies among vulnerable populations published between January 2018 and April 2019 in which over half were prospective, the most investigated populations were pregnant women and children. Racial/ethnic minorities, individuals of low socioeconomic status (SES), and those occupationally exposed were studied the least. The most studied persistent organic pollutants (POPs) were per-/poly-fluoroalkyl substances (PFAS), and the most studied non-POPs were phenols. Across chemical classes, studies found certain POPs (e.g., PFAS) and non-POPs (i.e., phenols, phthalates, and parabens) to be associated with gestational diabetes and dysregulated glucose metabolism. Results for other cardiometabolic health outcomes were inconsistent but suggested certain chemicals may negatively affect cardiometabolic health. Synthetic chemicals likely adversely affect cardiometabolic health, but current findings were inconclusive. Few recent studies focused on racial/ethnic minorities, low SES, and occupationally exposed populations. To address poor cardiometabolic health and related disparities, more studies across vulnerable populations are warranted.
目的综述：尽管弱势人群不成比例地暴露于具有内分泌干扰特性的合成化学物质之下，但很少有最新综述总结了这些人群中合成化学物质对心血管代谢健康的影响。
最近发现：在 2018 年 1 月至 2019 年 4 月期间发表的 37 项针对弱势人群的具有潜在作用的流行病学研究中，超过一半是前瞻性的，研究最多的人群是孕妇和儿童。种族/民族少数群体、社会经济地位较低的个体和职业暴露者的研究最少。研究最多的持久性有机污染物（POPs）是全氟/多氟烷基物质（PFAS），研究最多的非持久性有机污染物是酚类物质。在不同的化学物质类别中，研究发现某些 POPs（如 PFAS）和非 POPs（如酚类物质、邻苯二甲酸酯和对羟基苯甲酸酯）与妊娠糖尿病和葡萄糖代谢失调有关。其他心血管代谢健康结果的研究结果不一致，但表明某些化学物质可能对心血管代谢健康产生负面影响。合成化学物质可能会对心血管代谢健康产生不利影响，但目前的研究结果尚无定论。最近很少有研究关注种族/民族少数群体、社会经济地位较低的人群和职业暴露人群。为了解决较差的心血管代谢健康和相关差异问题，需要在弱势人群中开展更多研究。
