Arora Himanshu, Sawhney J P S, Mehta Ashwani, Mohanty Arun
Department of Cardiology, Sir Ganga Ram Hospital, New Delhi 110060, India.
Department of Cardiology, Sir Ganga Ram Hospital, New Delhi 110060, India.
Indian Heart J. 2018 Dec;70 Suppl 3(Suppl 3):S101-S104. doi: 10.1016/j.ihj.2018.06.017. Epub 2018 Jun 30.
Iron deficiency (ID) is an emerging problem in patients with congestive heart failure (CHF) and can be a potential therapeutic target. As ID is highly prevalent in the society, it is hypothesized that Indian patients with CHF have high prevalence of ID.
CHF patients (n = 275) were selected and underwent laboratory evaluation including hemoglobin concentration, serum iron, transferrin, ferritin, B12 and folate level.
Two hundred and seventy-five patients with heart failure (mean age - 62.72, mean Hb- 10.54 g/dl, 188 males [68.36%] and 87 females [31.64%]) were enrolled in the study. 211 out of 275 (76.7%) were found to be anemic. Out of 275 patients. 148 (53.8%) were diagnosed with iron deficiency. 12.7% (n = 35) were B12 deficient and 5.1% (n = 14) were folate deficient. In the anemic group, ID was present in 130 patients (61.61%), B12 deficiency in 32 patients (15.16%) and folate deficiency in 12 patients (5.68%). In the group of patients without anemia, ID was present in 18 patients (28.12%) while B12 and folate deficiency was present in 3 (4.68%) and 2 (3.12%) patients, respectively.
Iron deficiency is present in substantial number while B12 and folate account for a few number of cases. Substantial number of patients without anemia were found to be iron deficient.
缺铁（ID）在充血性心力衰竭（CHF）患者中是一个新出现的问题，可能是一个潜在的治疗靶点。由于ID在社会中高度流行，因此推测印度CHF患者中ID的患病率很高。
选取CHF患者（n = 275），并进行实验室评估，包括血红蛋白浓度、血清铁、转铁蛋白、铁蛋白、维生素B12和叶酸水平。
275例心力衰竭患者（平均年龄 - 62.72岁，平均血红蛋白 - 10.54 g/dl，男性188例[68.36%]，女性87例[31.64%]）纳入研究。275例中有211例（76.7%）被发现贫血。在275例患者中，148例（53.8%）被诊断为缺铁。12.7%（n = 35）维生素B12缺乏，5.1%（n = 14）叶酸缺乏。在贫血组中，130例患者（61.61%）存在ID，32例患者（15.16%）维生素B12缺乏，12例患者（5.68%）叶酸缺乏。在无贫血患者组中，18例患者（28.12%）存在ID，而分别有3例（4.68%）和2例（3.12%）患者存在维生素B12和叶酸缺乏。
大量患者存在缺铁，而维生素B12和叶酸缺乏的病例较少。发现大量无贫血患者存在缺铁。
