钠-碘同向转运体（SLC5A5）基因在甲状腺乳头状癌中的作用：一项系统评价
The Role of the NIS (SLC5A5) Gene in Papillary Thyroid Cancer: A Systematic Review.
作者信息
de Morais Rafael Martins, Sobrinho Alaor Barra, de Souza Silva Calliandra Maria, de Oliveira Jamila Reis, da Silva Izabel Cristina Rodrigues, de Toledo Nóbrega Otávio
机构信息
Post-Graduate in Medical Sciences Program, University of Brasília, Brasília, DF, Brazil.
Imagens Médicas de Brasília, Brasília, DF, Brazil.
出版信息
Int J Endocrinol. 2018 Nov 14;2018:9128754. doi: 10.1155/2018/9128754. eCollection 2018.
Papillary thyroid cancer (PTC) is the most common thyroid malignancy. Genetic and epigenetic alterations play a decisive role in the onset of several human neoplasms. Mutations and polymorphisms are two frequent genetic alterations. Located on chromosome 19 (19p13.11), the NIS SLC5A5 (solute carrier family 5 member 5) gene encodes a highly specialized and efficient 80-90 kDa transmembrane glycoprotein that mediates active transport of iodide from the bloodstream into the follicular cells. Given the highly significant role of NIS in the physiology and the cancer pathogenesis process, this paper's objective is to provide a comprehensive assessment of the associations between NIS gene and protein with papillary thyroid cancer.
甲状腺乳头状癌（PTC）是最常见的甲状腺恶性肿瘤。遗传和表观遗传改变在多种人类肿瘤的发生中起决定性作用。突变和多态性是两种常见的遗传改变。NIS SLC5A5（溶质载体家族5成员5）基因位于19号染色体（19p13.11）上，编码一种高度专业化且高效的80 - 90 kDa跨膜糖蛋白，该蛋白介导碘从血液主动转运到滤泡细胞中。鉴于NIS在生理学和癌症发病机制过程中的高度重要作用，本文的目的是全面评估NIS基因和蛋白与甲状腺乳头状癌之间的关联。
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