Bahadoori Azadeh, Shafa Amir, Ayoub Taha
Department of Anesthesiology, Isfahan University of Medical Sciences, Isfahan, Iran.
Adv Biomed Res. 2018 Nov 27;7:146. doi: 10.4103/abr.abr_82_18. eCollection 2018.
This study aimed to evaluate and compare the therapeutic effects of ephedrine and lidocaine in treatment of intraoperative hiccups in gynecologic surgery under sedation.
This randomized clinical trial in Isfahan was done on fifty female patients referring to Shahid Beheshti Hospital who needed to have sedation for medical interventions and they afflicted hiccups during surgery or sedation. Patients divided into two groups of 25 randomly assigned to one of the two groups of ephedrine or lidocaine. Ephedrine group received 5 mg/kg of medicine, while the lidocaine group was under treatment with 1 mg/kg lidocaine. Patients were monitored about systolic and diastolic blood pressure, MAP, heart rate, duration of hiccup, frequency of betterment, duration of intervention, and recovery at 15-min intervals of surgery and recovery.
Hiccups were resolved in 14 cases (56%) in the lidocaine group, while the improvement of such problem was achieved in 24 cases (96%) in ephedrine group ( < 0.001), so that the two groups did not have any significant difference in terms of the time of onset but the stop time of hiccups (relative to its start time) in the ephedrine group with the mean value of (2.40 ± 1.16) was significantly lower than the lidocaine group with the mean of 19.64 ± 22.76 min ( = 0.014). In addition, no complications were observed in the two groups.
Ephedrine has been more successful than lidocaine as a stimulant in controlling hiccups, and it has been able to suppress hiccups in a higher percentage of patients at a shorter time.
本研究旨在评估和比较麻黄碱与利多卡因在镇静下妇科手术中治疗术中呃逆的疗效。
在伊斯法罕进行的这项随机临床试验针对50名转诊至沙希德·贝赫什提医院的女性患者，她们因医疗干预需要镇静，且在手术或镇静过程中出现呃逆。患者被随机分为两组，每组25人，分别接受麻黄碱或利多卡因治疗。麻黄碱组接受5mg/kg的药物，而利多卡因组接受1mg/kg利多卡因治疗。在手术和恢复的15分钟间隔内，对患者的收缩压、舒张压、平均动脉压、心率、呃逆持续时间、好转频率、干预持续时间和恢复情况进行监测。
利多卡因组14例（56%）呃逆得到缓解，而麻黄碱组24例（96%）此类问题得到改善（P<0.001），两组在呃逆发作时间方面无显著差异，但麻黄碱组呃逆停止时间（相对于其开始时间）的平均值为（2.40±1.16）分钟，显著低于利多卡因组的平均值19.64±22.76分钟（P = 0.014）。此外，两组均未观察到并发症。
作为一种刺激剂，麻黄碱在控制呃逆方面比利多卡因更成功，并且能够在更短的时间内使更高比例的患者呃逆得到抑制。
