Van Merode T, Hick P J, Hoeks A P, Rahn K H, Reneman R S
Department of Physiology, University of Limburg, Maastricht, The Netherlands.
Ultrasound Med Biol. 1988;14(7):563-9. doi: 10.1016/0301-5629(88)90122-6.
The vessel wall properties of the common carotid artery were studied noninvasively in normotensive and borderline hypertensive male volunteers of various ages with the use of a multi-gate pulsed Doppler system. In the younger age group (20-35 y) both distensibility and cross-sectional compliance were significantly less in the borderline hypertensive group. In the older borderline hypertensive subjects (50-69 y) distensibility (p less than 0.05) and cross-sectional compliance (p = 0.06) were also less than in the control subjects. The reduced distensibility and cross-sectional compliance likely result from a decrease in arterial wall elasticity because the relative increase in common carotid artery diameter during systole is diminished in borderline hypertensives, despite the fact that their pulse pressure is similar to or higher than that in control subjects. The less pronounced differences in vessel wall properties between borderline hypertensive and normotensive volunteers in the older age group may be a consequence of the changes in these properties with age, partly masking the alterations due to borderline hypertension. Since the stiffer behavior of the common carotid artery in borderline hypertensives is associated with relatively slight changes in blood pressure, the question can be raised whether the alterations in arterial wall properties are really a result of the elevated arterial blood pressure; these alterations might develop independent of the blood pressure elevation.
利用多门脉冲多普勒系统，对不同年龄的血压正常和临界高血压男性志愿者的颈总动脉血管壁特性进行了无创研究。在较年轻年龄组（20 - 35岁），临界高血压组的扩张性和横截面积顺应性均显著降低。在年龄较大的临界高血压受试者（50 - 69岁）中，扩张性（p < 0.05）和横截面积顺应性（p = 0.06）也低于对照组。扩张性和横截面积顺应性降低可能是由于动脉壁弹性下降所致，因为在临界高血压患者中，尽管其脉压与对照组相似或更高，但收缩期颈总动脉直径的相对增加却减小了。在年龄较大的组中，临界高血压志愿者与血压正常志愿者之间血管壁特性差异不太明显，这可能是这些特性随年龄变化的结果，部分掩盖了临界高血压引起的改变。由于临界高血压患者颈总动脉的僵硬表现与血压相对轻微的变化有关，因此可以提出这样的问题，即动脉壁特性的改变是否真的是动脉血压升高的结果；这些改变可能独立于血压升高而发生。
