Differences in carotid artery wall properties between presumed-healthy men and women.

The vessel wall properties of the common carotid artery were noninvasively studied in 109 normotensive, presumed normal male and female volunteers of various ages (20-69 y) with the use of a multi-gate pulsed Doppler system. This system allows the on-line recording of velocity profiles and the relative changes in carotid artery diameter during the cardiac cycle (delta d/d). From the width of these profiles the systolic internal diameter (d) of the carotid artery can be determined. With the use of d, the maximal increase in delta d/d during systole and the pulse pressure, as measured in the brachial artery (delta p), the distensibility coefficient and the cross-sectional compliance were calculated. Both distensibility and cross-sectional compliance were significantly lower in females than in males, irrespective of age. This likely results from a stiffer arterial wall behavior in females, because the relative increase in vessel diameter during the cardiac cycle is lower in females than in males, despite the fact that their pulse pressure values are not significantly different. The carotid artery diameters were similar in men and women. The findings in the present study indicate that the common carotid artery is stiffer in females than in males of comparable age. Therefore, sex-dependent differences have to be considered in the interpretation of arterial distensibility and cross-sectional compliance.