Masters J R, Vesey S G, Munn C F, Evan G I, Watson J V
Institute of Urology, St. Paul's Hospital, London, United Kingdom.
Urol Res. 1988;16(5):341-4. doi: 10.1007/BF00256039.
The protein coded by the oncogene c-myc, p62c-myc, was measured using monoclonal antibodies and flow cytometry in nuclei derived from paraffin-wax sections of transitional cell carcinomas of the human bladder. Superficial disease (stages pTa and pT1) which did not recur within 5 years of diagnosis had significantly higher oncoprotein levels than those which did recur or were muscle-invasive (stage pT2 or greater) at presentation (P less than 0.01). These preliminary findings indicate that oncoprotein levels might have prognostic significance for bladder cancer.
使用单克隆抗体和流式细胞术，在源自人膀胱移行细胞癌石蜡切片的细胞核中检测癌基因c-myc编码的蛋白质p62c-myc。诊断后5年内未复发的浅表性疾病（pTa和pT1期），其癌蛋白水平显著高于那些复发或在初诊时为肌层浸润性（pT2期或更高）的疾病（P<0.01）。这些初步研究结果表明，癌蛋白水平可能对膀胱癌具有预后意义。
