在 2 个帕金森病队列中可重现地检测黑质铁沉积。
Reproducible detection of nigral iron deposition in 2 Parkinson's disease cohorts.
机构信息
Center for Advanced Neuroimaging, University of California, Riverside, Riverside, California, USA.
Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
出版信息
Mov Disord. 2019 Mar;34(3):416-419. doi: 10.1002/mds.27608. Epub 2018 Dec 30.
BACKGROUND
Previous studies investigating nigral iron accumulation used T or T *-weighted contrasts to define the regions of interest (ROIs) in the substantia nigra with mixed results. Because these contrasts are not sensitive to neuromelanin, ROIs may have inadvertently missed the SNpc. An approach sensitive to neuromelanin should yield consistent results. We examine iron deposition in ROIs derived from neuromelanin-sensitive and T *-weighted contrasts, respectively.
METHODS
T -weighted and multiecho gradient echo imaging data were obtained in 2 cohorts. Multiecho gradient echo imaging data were analyzed using neuromelanin-sensitive SNpc ROIs as well as T *-weighted SNr ROIs.
RESULTS
When compared with controls, significantly larger R * values were seen in the SNpc of PD patients in both cohorts. Mean R * values in the SNr of PD patients showed no consistency, with 1 cohort showing a small, statistically significant increase, whereas the other cohort exhibited no statistical difference.
CONCLUSION
Mean R * in the SNpc defined by neuromelanin-sensitive MRI is significantly increased in PD. © 2018 International Parkinson and Movement Disorder Society.
背景
先前研究黑质中铁积累的研究使用 T 或 T*-加权对比来定义感兴趣区（ROI），结果不一。因为这些对比对神经黑色素不敏感，ROI 可能无意中错过了 SNpc。对神经黑色素敏感的方法应该会产生一致的结果。我们分别检查了来自神经黑色素敏感和 T*-加权对比的 ROI 中的铁沉积。
方法
在 2 个队列中获得 T-加权和多回波梯度回波成像数据。使用神经黑色素敏感的 SNpc ROI 以及 T*-加权的 SNr ROI 对多回波梯度回波成像数据进行分析。
结果
与对照组相比，两个队列的 PD 患者的 SNpc 中均可见到明显更大的 R值。PD 患者 SNr 中的平均 R值没有一致性，一个队列显示出小的、统计学上显著的增加，而另一个队列则没有统计学差异。
结论
用神经黑色素敏感 MRI 定义的 SNpc 中的平均 R*在 PD 中显著增加。© 2018 国际帕金森病和运动障碍协会。
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