衰老过程中富含铁的灰质核团中铁与平均峰度之间的关联。
Associations between iron and mean kurtosis in iron-rich grey matter nuclei in aging.
作者信息
Langley Jason, Solis Kitzia, Masjedizadeh Vala, Shao Murphy, Bennett Ilana, Hu Xiaoping P
机构信息
Center for Advanced Neuroimaging, University of California Riverside, Riverside, CA, USA.
Department of Psychology, University of California Riverside, Riverside, CA, USA.
出版信息
ArXiv. 2025 May 15:arXiv:2501.04706v2.
Mean kurtosis in iron-rich grey matter has values similar to that seen in white matter. We suspect these elevated values may be related to iron. Multi-shell diffusion and multi-echo gradient echo acquisitions were used to derive mean kurtosis and R*, respectively. Mean kurtosis and R* were measured in subcortical grey matter nuclei and white matter tracts in 93 older adults and 62 younger adults. Grey matter regions exhibited higher mean kurtosis and R* in the older adult group whereas white matter regions had reduced mean kurtosis in the older adult group. Grey matter mean kurtosis was significantly correlated with R* iron-rich grey matter nuclei in both groups. Our findings indicate that higher mean kurtosis in iron-rich grey matter structures may be due to either increased tissue complexity or to decreases in signal-to-noise ratios from iron deposition.
富含铁的灰质中的平均峰度值与白质中的相似。我们怀疑这些升高的值可能与铁有关。分别使用多壳扩散和多回波梯度回波采集来得出平均峰度和R*。在93名老年人和62名年轻人的皮质下灰质核和白质束中测量了平均峰度和R*。在老年组中，灰质区域表现出更高的平均峰度和R*，而白质区域的平均峰度则降低。两组中，灰质平均峰度与富含铁的灰质核中的R*均显著相关。我们的研究结果表明，富含铁的灰质结构中较高的平均峰度可能是由于组织复杂性增加或铁沉积导致的信噪比降低。
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