移动技术在变应性鼻炎治疗中的应用。MASK 研究。

Adherence to treatment in allergic rhinitis using mobile technology. The MASK Study.

机构信息

CIRFF, Center of Pharmacoeconomics, University of Naples Federico II, Naples, Italy.

UCIBIO, REQUIMTE, Faculty of Pharmacy, and Competence Center on Active and Healthy Ageing of University of Porto (Porto4Ageing), University of Porto, Porto, Portugal.

出版信息

Clin Exp Allergy. 2019 Apr;49(4):442-460. doi: 10.1111/cea.13333. Epub 2019 Mar 12.

DOI:10.1111/cea.13333

PMID:30597673

Abstract

BACKGROUND

Mobile technology may help to better understand the adherence to treatment. MASK-rhinitis (Mobile Airways Sentinel NetworK for allergic rhinitis) is a patient-centred ICT system. A mobile phone app (the Allergy Diary) central to MASK is available in 22 countries.

OBJECTIVES

To assess the adherence to treatment in allergic rhinitis patients using the Allergy Diary App.

METHODS

An observational cross-sectional study was carried out on all users who filled in the Allergy Diary from 1 January 2016 to 1 August 2017. Secondary adherence was assessed by using the modified Medication Possession Ratio (MPR) and the Proportion of days covered (PDC) approach.

RESULTS

A total of 12 143 users were registered. A total of 6 949 users reported at least one VAS data recording. Among them, 1 887 users reported ≥7 VAS data. About 1 195 subjects were included in the analysis of adherence. One hundred and thirty-six (11.28%) users were adherent (MPR ≥70% and PDC ≤1.25), 51 (4.23%) were partly adherent (MPR ≥70% and PDC = 1.50) and 176 (14.60%) were switchers. On the other hand, 832 (69.05%) users were non-adherent to medications (MPR <70%). Of those, the largest group was non-adherent to medications and the time interval was increased in 442 (36.68%) users.

CONCLUSION AND CLINICAL RELEVANCE

Adherence to treatment is low. The relative efficacy of continuous vs on-demand treatment for allergic rhinitis symptoms is still a matter of debate. This study shows an approach for measuring retrospective adherence based on a mobile app. This also represents a novel approach for analysing medication-taking behaviour in a real-world setting.

摘要

背景

移动技术可能有助于更好地了解治疗的依从性。MASK-rhinitis（过敏症移动航空哨兵网络）是以患者为中心的 ICT 系统。MASK 中心的一个移动电话应用程序（过敏日记）在 22 个国家/地区可用。

目的

使用过敏日记应用程序评估过敏性鼻炎患者的治疗依从性。

方法

对 2016 年 1 月 1 日至 2017 年 8 月 1 日期间填写过敏日记的所有用户进行了一项观察性横断面研究。采用改良药物使用比例（MPR）和覆盖天数比例（PDC）方法评估次要依从性。

结果

共注册了 12143 名用户。共有 6949 名用户报告了至少一次 VAS 数据记录。其中，1887 名用户报告了≥7 次 VAS 数据。在依从性分析中纳入了 1195 名受试者。136 名（11.28%）患者为依从者（MPR≥70%且 PDC≤1.25），51 名（4.23%）为部分依从者（MPR≥70%且 PDC=1.50），176 名（14.60%）为转换者。另一方面，832 名（69.05%）患者不依从药物治疗（MPR<70%）。其中，最大的一组是不依从药物治疗，并且 442 名（36.68%）患者增加了药物治疗的时间间隔。