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移动技术为过敏性鼻炎的控制和治疗提供了新的见解:MASK 研究。

Mobile technology offers novel insights into the control and treatment of allergic rhinitis: The MASK study.

机构信息

ISGlobal, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain.

UPRES EA220, Pôle des Maladies des Voies Respiratoires, Hôpital Foch, Université Paris-Saclay, Suresnes, France.

出版信息

J Allergy Clin Immunol. 2019 Jul;144(1):135-143.e6. doi: 10.1016/j.jaci.2019.01.053. Epub 2019 Apr 3.

Abstract

BACKGROUND

Mobile health can be used to generate innovative insights into optimizing treatment to improve allergic rhinitis (AR) control.

OBJECTIVES

A cross-sectional real-world observational study was undertaken in 22 countries to complement a pilot study and provide novel information on medication use, disease control, and work productivity in the everyday life of patients with AR.

METHODS

A mobile phone app (Allergy Diary, which is freely available on Google Play and Apple stores) was used to collect the data of daily visual analogue scale (VAS) scores for (1) overall allergic symptoms; (2) nasal, ocular, and asthma symptoms; (3) work; and (4) medication use by using a treatment scroll list including all allergy medications (prescribed and over-the-counter) customized for 22 countries. The 4 most common intranasal medications containing intranasal corticosteroids and 8 oral H-antihistamines were studied.

RESULTS

Nine thousand one hundred twenty-two users filled in 112,054 days of VASs in 2016 and 2017. Assessment of days was informative. Control of days with rhinitis differed between no (best control), single (good control for intranasal corticosteroid-treated days), or multiple (worst control) treatments. Users with the worst control increased the range of treatments being used. The same trend was found for asthma, eye symptoms, and work productivity. Differences between oral H-antihistamines were found.

CONCLUSIONS

This study confirms the usefulness of the Allergy Diary in accessing and assessing behavior in patients with AR. This observational study using a very simple assessment tool (VAS) on a mobile phone had the potential to answer questions previously thought infeasible.

摘要

背景

移动医疗可用于生成创新见解,以优化治疗方案,从而改善过敏性鼻炎(AR)的控制效果。

目的

在 22 个国家开展了一项横断面真实世界观察性研究,旨在对试点研究进行补充,并提供有关患者在日常生活中使用药物、控制疾病和工作生产力方面的新颖信息。

方法

使用手机应用程序(Allergy Diary,可在 Google Play 和 Apple store 上免费获得)收集患者每日视觉模拟量表(VAS)评分数据,包括(1)整体过敏症状;(2)鼻、眼和哮喘症状;(3)工作;以及(4)使用治疗滚动列表(包含所有为 22 个国家定制的过敏药物,包括处方和非处方药物)记录药物使用情况。研究了 4 种最常见的含有鼻内皮质类固醇和 8 种口服 H1 抗组胺药的鼻内药物。

结果

2016 年和 2017 年,9122 名用户填写了 112054 天的 VAS。对评估天数的分析表明,鼻炎控制情况在无治疗(最佳控制)、单一治疗(鼻内皮质类固醇治疗日的良好控制)或多种治疗(最差控制)之间存在差异。控制最差的患者增加了所使用药物的种类。哮喘、眼部症状和工作生产力也存在同样的趋势。口服 H1 抗组胺药之间存在差异。

结论

本研究证实了 Allergy Diary 用于获取和评估 AR 患者行为的有用性。这项使用手机上非常简单的评估工具(VAS)进行的观察性研究,有可能回答以前认为不可行的问题。

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