Amsterdam Rehabilitation Research Center|Reade, Amsterdam, The Netherlands.
Department of Rehabilitation Medicine, Amsterdam Public Health Research Institute, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Rheumatol Int. 2019 Feb;39(2):277-284. doi: 10.1007/s00296-018-4223-x. Epub 2019 Jan 2.
The aims of this study were (1) to describe dietary protein intake, and (2) to evaluate the association between dietary protein intake and upper leg muscle strength in subjects with knee osteoarthritis (OA). Baseline data from the OA was used, in a cross-sectional study. All subjects were diagnosed with symptomatic and radiographic knee OA. Daily dietary protein intake was measured with the Block Brief 2000 food frequency questionnaire (g/kg body weight). The sum of knee flexion and extension strength of the index knee (N/kg bodyweight) was assessed with the Good Strength chair test. Linear regression analysis was used to test the association between dietary protein intake and muscle strength, adjusting for relevant confounders. Data from 1316 subjects (mean age 61.4 ± SD 9.1 years, 57.0% female) were used. The mean daily protein intake was 0.72 ± SD 0.30 g/kg bodyweight, and 65.1% of the subjects had a protein intake lower than the recommended daily allowance of 0.8 g/kg bodyweight. The mean muscle strength was 5.4 ± SD 2.1 N/kg bodyweight. Lower protein intake was significantly associated with lower muscle strength (B = 0.583, 95% CI 0.230-0.936, p = 0.001). The majority of the subjects with knee OA had a dietary protein intake lower than the recommended daily allowance. Lower protein intake was associated with lower upper leg muscle strength. Longitudinal observational and interventional studies are needed to establish whether dietary protein intake has a causal effect on muscle strength in subjects with knee OA.
(1)描述膳食蛋白质的摄入量，以及 (2)评估膝关节骨关节炎（OA）患者膳食蛋白质摄入量与大腿肌肉力量之间的关系。本研究使用了一项横断面研究的 OA 基线数据。所有患者均被诊断为有症状和影像学膝关节 OA。通过 Block Brief 2000 食物频率问卷（g/kg 体重）来测量每日膳食蛋白质摄入量。使用 Good Strength 椅子测试评估索引膝关节的膝关节屈伸力量总和（N/kg 体重）。采用线性回归分析来检验膳食蛋白质摄入量与肌肉力量之间的关联，同时调整了相关混杂因素。本研究共纳入了 1316 名受试者（平均年龄 61.4±9.1 岁，57.0%为女性）。平均每日蛋白质摄入量为 0.72±0.30 g/kg 体重，65.1%的受试者蛋白质摄入量低于推荐的每日 0.8 g/kg 体重的摄入量。平均肌肉力量为 5.4±2.1 N/kg 体重。较低的蛋白质摄入量与较低的肌肉力量显著相关（B=0.583，95%CI 0.230-0.936，p=0.001）。大多数膝关节 OA 患者的膳食蛋白质摄入量低于推荐的每日摄入量。较低的蛋白质摄入量与较低的大腿肌肉力量相关。需要进行纵向观察性和干预性研究，以确定膳食蛋白质摄入量对膝关节 OA 患者肌肉力量是否有因果关系。
