Wang Xue, Cao Xudong, Zhang Wanjiang, Zhang Le, Lu Lijun, Li Xinyue, El-Ashram Saeed, Wu Jiangdong, Chen Chuangfu
Key Laboratory of Xinjiang Endemic and Ethnic Diseases Cooperated by Education Ministry with Xinjiang Province, Shihezi University, Shihezi, China.
College of Life Science and Engineering, Foshan University, Foshan, China.
Mol Genet Genomic Med. 2019 Mar;7(3):e544. doi: 10.1002/mgg3.544. Epub 2019 Jan 1.
Tuberculosis (TB) is the second-leading cause of death globally. Genetic polymorphisms in human leukocyte antigens (HLA)-DQB2, HLA-DPA1, and HLA-DPB1 may partly explain individual differences in TB susceptibility.
We performed a hospital-based case-control study to assess the genetic influence of single-nucleotide polymorphisms (SNPs) in the HLA (HLA-DPA, HLA-DPB, and HLA-DQB) on the development of TB. There were 248 TB-infected cases and 340 healthy controls in this study.
The HLA-DQB2 rs7453920 genotype GG was applied as the reference group, the GA genotype was related to a considerably magnified risk of TB (GA vs. GG: adjusted OR = 1.547, 95% CI = 1.039-2.304, p = 0.032). Nevertheless, the other two SNPs were not associated with TB risk. Stratified analyses suggested that tobacco was associated with an increased risk of TB in HLA-DQB2 rs7453920 G>A.
These results suggested that the functional HLA-DQB2 rs7453920 G>A polymorphism may contribute to the genetic susceptibility to TB. Nevertheless, the results were based on a limited sample size, and larger well-designed studies are expected to confirm these preliminary findings.
结核病（TB）是全球第二大致死原因。人类白细胞抗原（HLA）-DQB2、HLA-DPA1和HLA-DPB1中的基因多态性可能部分解释了个体对结核病易感性的差异。
我们开展了一项基于医院的病例对照研究，以评估HLA（HLA-DPA、HLA-DPB和HLA-DQB）中单核苷酸多态性（SNP）对结核病发生的遗传影响。本研究中有248例结核病感染病例和340名健康对照。
将HLA-DQB2 rs7453920基因型GG作为参照组，GA基因型与结核病风险显著升高相关（GA与GG比较：校正比值比=1.547，95%置信区间=1.039-2.304，p=0.032）。然而，其他两个SNP与结核病风险无关。分层分析表明，在HLA-DQB2 rs7453920 G>A中，烟草与结核病风险增加相关。
这些结果表明，功能性HLA-DQB2 rs7453920 G>A多态性可能导致对结核病的遗传易感性。然而，这些结果基于有限的样本量，预计需要更大规模的精心设计研究来证实这些初步发现。
