Avelar Amado Paula, Fonsêca Castro Ana Hortência, Nunes Alves Stênio, Brentan Silva Denise, Alexandre Carollo Carlos, Alves Rodrigues Dos Santos Lima Luciana
Programa de Pós-Graduação em Biotecnologia, Divinópolis, MG, Brazil.
Programa de Pós-Graduação em Ciências Farmacêuticas, Divinópolis, MG, Brazil.
Nat Prod Res. 2020 Sep;34(17):2545-2553. doi: 10.1080/14786419.2018.1543678. Epub 2019 Jan 2.
is a medicinal species of the Brazilian Cerrado. The extract and fractions of this plant were analysed by LC-DAD-MS. Identified constituents included glycosylated and non-glycosylated flavonoids, especially quercetin, and phenylpropanoids, such as chlorogenic acids. The antioxidant activity was significantly more pronounced for the methanol extract and fractions than that of the commercial antioxidant 2,6-di-tert-butyl-4-methylphenol (BHT). Maximum larvicidal activity of 85.83% was recorded in the dichloromethane fraction (LC = 469.78 µg mL). The methanol extract and fractions presented low toxicity to larvae of the shrimp brine indicating selectivity for . These results contribute to the phytochemical study of . These compounds were identified for the first time in this species and encourage additional work on the isolation of compounds present in the extract and fractions of to evaluate the possibility of using them as natural sources of antioxidants, since cytotoxic effects were not demonstrated.
是巴西塞拉多地区的一种药用植物。采用液相色谱-二极管阵列检测器-质谱联用（LC-DAD-MS）对该植物的提取物和馏分进行了分析。鉴定出的成分包括糖基化和非糖基化黄酮类化合物，尤其是槲皮素，以及苯丙素类化合物，如绿原酸。甲醇提取物和馏分的抗氧化活性明显高于商业抗氧化剂2,6-二叔丁基-4-甲基苯酚（BHT）。二氯甲烷馏分的杀幼虫活性最高，为85.83%（LC = 469.78 µg mL）。甲醇提取物和馏分对虾卤幼虫的毒性较低，表明对其具有选择性。这些结果有助于对该植物进行植物化学研究。这些化合物首次在该物种中被鉴定出来，并且由于未显示出细胞毒性作用，因此鼓励进一步开展工作，从该植物的提取物和馏分中分离化合物，以评估将它们用作天然抗氧化剂来源的可能性。
