College of Chemistry, National & Local Joint Biomedical Engineering Research Center on Photodynamic Technologies, State Key Laboratory of Photocatalysis on Energy and Environment, Fuzhou University, Fuzhou, China.
Chem Commun (Camb). 2019 Jan 15;55(6):866-869. doi: 10.1039/c8cc09456j.
We designed and synthesized a simple, but highly effective photosensitizer (G-Mito-Pc), which can precisely target the mitochondria of epidermal growth factor receptor (EGFR)-overexpressing cancer cells, to achieve dual targeting function at both cell and organelle levels in cancer therapy. We further explored the possible molecular mechanism of the enhanced bioactivity of G-Mito-Pc compared to that of the reference photosensitizer using molecular dynamics simulations on their interactions with a physiologically relevant mitochondrial membrane model.
我们设计并合成了一种简单但高效的光敏剂（G-Mito-Pc），它可以精确靶向表皮生长因子受体（EGFR）过表达癌细胞的线粒体，在癌症治疗中实现细胞和细胞器水平的双重靶向功能。我们进一步通过分子动力学模拟研究了 G-Mito-Pc 与生理相关的线粒体膜模型相互作用，探讨了其与参比光敏剂相比增强生物活性的可能分子机制。
