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用于线粒体靶向、双光子成像引导光动力治疗的溴螨酯咪唑基取代硅酞菁

Bromopropylate Imidazoliumyl Substituted Silicon Phthalocyanine for Mitochondria-Targeting, Two-Photon Imaging Guided Photodynamic Therapy.

作者信息

Chen Kuizhi, Hou Jialin, Huang Bingcheng, Xiao Shuanghuang, Li Xia, Sun Hong, Peng Yiru

机构信息

Fujian Provincial Key Laboratory of Advanced Materials Oriented Chemical Engineering, Fujian Provincial Key Laboratory of Polymer Materials, College of Chemistry and Materials, Fujian Normal University, Fuzhou, China.

Department of Breast Surgery, Fujian Medical University Union Hospital, Fuzhou, China.

出版信息

Front Pharmacol. 2022 Jul 12;13:921718. doi: 10.3389/fphar.2022.921718. eCollection 2022.

DOI:10.3389/fphar.2022.921718
PMID:35903336
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9315426/
Abstract

Maximization of phototoxic damage on tumor is essential for effective anticancer photodynamic therapy (PDT). Highly cancer-cell-organelle-specific delivery of efficient photosensitizers (PSs) and is in great demand. In this paper, a novel water-soluble mitochondria targeted cationic bromopropylate imidazoliumyl axially substituted silicon (IV) phthalocyanine (Br-ID-SiPc) is developed to improve PDT efficiency by enhancing the subcellular localization of photosensitizers. Benefiting from the targeting capability of bromopropylate imidazoliumyl, Br-ID-SiPc can selectively accumulate in mitochondria after cellular uptake, this process could be tracked by two-photon imaging. Br-ID-SiPc effectively damaged the circular plasmid DNA of mitochondria and induced HO-8910 cells apoptosis. Our results indicate that Br-ID-SiPc is a potential photosensitizer which can be used as a mitochondria-targeting and two-photon fluorescent imaging molecule for PDT of cancers.

摘要

使肿瘤上的光毒性损伤最大化对于有效的抗癌光动力疗法（PDT）至关重要。高效光敏剂（PSs）向癌细胞细胞器的高度特异性递送非常必要。本文开发了一种新型的水溶性线粒体靶向阳离子溴丙酯咪唑轴向取代硅（IV）酞菁（Br-ID-SiPc），通过增强光敏剂的亚细胞定位来提高PDT效率。得益于溴丙酯咪唑的靶向能力，Br-ID-SiPc在细胞摄取后可选择性地在线粒体中积累，这一过程可通过双光子成像进行追踪。Br-ID-SiPc有效地破坏了线粒体的环状质粒DNA并诱导HO-8910细胞凋亡。我们的结果表明，Br-ID-SiPc是一种潜在的光敏剂，可作为用于癌症PDT的线粒体靶向和双光子荧光成像分子。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ec1/9315426/d1097d5ed89a/fphar-13-921718-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ec1/9315426/e4be7f152c07/fphar-13-921718-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ec1/9315426/324a1e951c48/fphar-13-921718-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ec1/9315426/c15f0e9512f6/fphar-13-921718-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ec1/9315426/02facadb790b/fphar-13-921718-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ec1/9315426/682ba9ad6416/fphar-13-921718-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ec1/9315426/9d71f9876981/fphar-13-921718-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ec1/9315426/d1097d5ed89a/fphar-13-921718-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ec1/9315426/e4be7f152c07/fphar-13-921718-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ec1/9315426/324a1e951c48/fphar-13-921718-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ec1/9315426/c15f0e9512f6/fphar-13-921718-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ec1/9315426/02facadb790b/fphar-13-921718-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ec1/9315426/682ba9ad6416/fphar-13-921718-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ec1/9315426/9d71f9876981/fphar-13-921718-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ec1/9315426/d1097d5ed89a/fphar-13-921718-g007.jpg

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