Advanced Functional Material Laboratory, Tezpur University (Central University), Tezpur 784028, India.
Dalton Trans. 2019 Jan 15;48(3):1075-1083. doi: 10.1039/c8dt04038a.
The accuracy of magnetic resonance imaging (MRI) scanning can be improved using a multifunctional nanosystem having T1-T2 dual contrast enhancement. Specifically, the combination of both T1 and T2 effects in a single system helps in acquiring cross validated information during dual mode MRI and reduces the required dose. In this study, polyethylene glycol (PEG) stabilized MnFe2O4@MnO Janus nanoparticles were developed as novel dual-mode MR imaging agents. MnO contributed to T1 contrast whereas MnFe2O4 enabled T2 contrast. The PEG molecules afforded solubility and stability to the contrast agent in water, making it acceptable for biomedical purposes. The biocompatibility of the developed nanosystem was confirmed by cell viability studies. The r2/r1 ratio remained at a suitable value, justifying the applicability of the contrast agent for dual mode MRI. Finally, the efficiency of the agent for T1-T2 contrast enhancement was confirmed through in vitro and ex vivo MRI experiments.
磁共振成像（MRI）扫描的准确性可以通过使用具有 T1-T2 双重对比增强功能的多功能纳米系统来提高。具体来说，在单一系统中同时结合 T1 和 T2 效应有助于在双模 MRI 期间获得相互验证的信息，并减少所需的剂量。在这项研究中，开发了聚乙二醇（PEG）稳定的 MnFe2O4@MnO 双凸纳米粒子作为新型双模磁共振成像造影剂。MnO 有助于 T1 对比，而 MnFe2O4 则实现了 T2 对比。PEG 分子赋予造影剂在水中的溶解度和稳定性，使其可用于生物医学目的。通过细胞活力研究证实了所开发的纳米系统的生物相容性。r2/r1 比值保持在合适的值，证明了该造影剂适用于双模 MRI。最后，通过体外和体内 MRI 实验证实了该试剂用于 T1-T2 对比增强的效率。
