Hengshui University , Hengshui , Hebei 053000 , P. R. China.
Department of Bionanochemistry , Wonkwang University , Chonbuk, Iksan 570-749 , Republic of Korea.
Langmuir. 2019 Jul 23;35(29):9474-9482. doi: 10.1021/acs.langmuir.9b00736. Epub 2019 Jul 8.
The - dual-mode contrast agents for magnetic resonance imaging (MRI) can generate self-complementary confirmed and images, hence greatly improving the reliability. Facilely synthesizing nanoparticles with the ultrasensitive contrast property remains extremely challenging in nanoscience. Moreover, uncovering the mechanism correlating the signal enhancements and chemical constituents is vital for designing novel efficient synergistically enhanced - dual-mode MRI nanoprobes. Herein, we report a one-pot facile method to synthesize the superparamagnetic manganese oxide-doped iron oxide (FeO/MnO) nanoparticles for - dual-mode MR imaging. Under external magnetic field, the local magnetic field intensities of MnO and FeO could be simultaneously enhanced through embedding MnO into FeO nanoparticles and hence can cause synergistic and contrast enhancements. Moreover, a novel and facile cost-effective method for large-scale synthesis of hydroxyl-polyethylene glycol-phosphonic acid-stabilizing ligands is designed. The facile synthetic method and surface coating strategy of superparamagnetic FeO/MnO nanoparticles offer an idea for the chemical design and preparation of superparamagnetic nanoparticles with ultrasensitive MRI contrast abilities for disease evaluation and treatment.
用于磁共振成像（MRI）的双模式对比剂可以产生自互补的 T1 和 T2 加权图像，从而大大提高了可靠性。在纳米科学中，很容易就能合成具有超灵敏对比性能的纳米粒子，但这仍然极具挑战性。此外，揭示与信号增强和化学成分相关的机制对于设计新型高效协同增强的双模式 MRI 纳米探针至关重要。在此，我们报告了一种简便的一锅法来合成超顺磁性氧化锰掺杂氧化铁（FeO/MnO）纳米粒子，用于双模式磁共振成像。在外磁场下，通过将 MnO 嵌入 FeO 纳米粒子中，可以同时增强 MnO 和 FeO 的局部磁场强度，从而可以协同增强 T1 和 T2 对比。此外，还设计了一种新颖且经济高效的大规模合成羟基-聚乙二醇-膦酸稳定配体的方法。超顺磁性 FeO/MnO 纳米粒子的简便合成方法和表面涂层策略为具有超灵敏 MRI 对比能力的超顺磁性纳米粒子的化学设计和制备提供了思路，可用于疾病评估和治疗。
