Maastricht MultiModal Molecular Imaging (M4I) institute, Division of Imaging Mass Spectrometry, Maastricht University, Universiteitssingel 50, 6229 ER, Maastricht, The Netherlands.
Lipidomics Consulting Ltd., Esbo, Finland.
Angew Chem Int Ed Engl. 2019 May 13;58(20):6492-6501. doi: 10.1002/anie.201812698. Epub 2019 Feb 18.
Lipidomics is a rapidly growing field with numerous examples showing the importance of lipid molecules throughout biology. It has also shed light onto the vast and complex functions performed by many lipids that possess an immense diversity in molecular structures. Mass spectrometry (MS) is the tool of choice for analyzing lipids and has been the key catalyst driving the field forward. However, MS does not yet permit true molecular lipidomics wherein the identification and quantification of lipids having defined molecular structures can be routinely achieved. Here we describe recent advances in MS-based lipidomics that allow access to higher levels of molecular information in lipidomics experiments. These advances will form a key piece of the puzzle as the field moves towards systems characterization of lipids at the molecular level.
脂质组学是一个快速发展的领域，有许多例子表明脂质分子在整个生物学中都很重要。它还揭示了许多脂质所具有的广泛而复杂的功能，这些脂质在分子结构上具有巨大的多样性。质谱（MS）是分析脂质的首选工具，也是推动该领域发展的关键催化剂。然而，MS 还不能实现真正的分子脂质组学，即在常规条件下实现对具有特定分子结构的脂质的鉴定和定量。在这里，我们描述了基于 MS 的脂质组学的最新进展，这些进展使我们能够在脂质组学实验中获得更高水平的分子信息。随着该领域朝着在分子水平上对脂质进行系统表征的方向发展，这些进展将成为解决问题的关键部分。
