Campos-de-Carvalho A C
Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Brasil.
Braz J Med Biol Res. 1988;21(2):177-88.
Regulation of gap junctional channels by voltage, calcium, pH and cyclic nucleotides is discussed, with emphasis on the physiological significance of each regulatory mechanism. The range of calcium and hydrogen ion concentrations that shut the junctional channels makes it unlikely that these ions may act as physiological modulators of intercellular communication. On the other hand, voltage and cyclic nucleotides in particular seem to play a physiologically significant role in the modulation of intercellular communication by way of gap junctions.
文中讨论了电压、钙、pH值和环核苷酸对间隙连接通道的调节作用，并着重阐述了每种调节机制的生理意义。能使连接通道关闭的钙和氢离子浓度范围表明，这些离子不太可能作为细胞间通讯的生理调节因子。另一方面，电压尤其是环核苷酸似乎在通过间隙连接调节细胞间通讯方面发挥着重要的生理作用。
