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缝隙连接电导:对氢离子和钙离子敏感性的比较。

Gap junctional conductance: comparison of sensitivities to H and Ca ions.

作者信息

Spray D C, Stern J H, Harris A L, Bennett M V

出版信息

Proc Natl Acad Sci U S A. 1982 Jan;79(2):441-5. doi: 10.1073/pnas.79.2.441.

Abstract

One cytoplasmic aspect of the junctional membrane between coupled pairs of Fundulus blastomeres was perfused with solutions of known H and Ca ion concentrations. Conductance of junctional membrane was decreased by either ion. The sensitivity to H ions was about 10,000 times greater than that to Ca ions. The results suggest that junctional conductance can be modulated by changes in H ion concentration near physiological pH, but that unphysiologically high concentrations of Ca ion, such as would be reached only on cell death, are required for comparable changes in junctional conductance.

摘要

用已知氢离子和钙离子浓度的溶液灌注Fundulus(底鳉)卵裂球耦合对之间连接膜的一个细胞质方面。两种离子都会降低连接膜的电导。对氢离子的敏感性比对钙离子的敏感性大约高10000倍。结果表明,在生理pH值附近,氢离子浓度的变化可以调节连接电导,但连接电导发生类似变化需要非生理性的高钙离子浓度,例如只有在细胞死亡时才会达到的浓度。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d1c/345759/fe0770c2419c/pnas00441-0242-a.jpg

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