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连接通透性的调节。

Modulation of junctional permeability.

作者信息

De Mello W C

出版信息

Fed Proc. 1984 Sep;43(12):2692-6.

PMID:6088293
Abstract

Changes in intercellular coupling can be accomplished by continuous synthesis and destruction of intercellular channels and through a modulation of unit channel permeability. The increase in free [Ca2+]i caused by activation of sodium-calcium exchange or by metabolic inhibition leads to cell decoupling. In embryonic cells the conductance of the gap junction is strongly dependent on pHi. The exact role of Ca2+ and H+ in the physiological modulation of junctional conductance remains unknown. The cyclic AMP (cAMP)-calcium hypothesis is presented. According to this view, cAMP modulates the junctional permeability through specific kinases. A feedback mechanism between calcium and cAMP might be relevant in the physiological control of junctional conductance.

摘要

细胞间偶联的变化可通过细胞间通道的持续合成与破坏以及单位通道通透性的调节来实现。钠钙交换激活或代谢抑制所导致的游离[Ca2+]i升高会引起细胞解偶联。在胚胎细胞中，间隙连接的电导强烈依赖于细胞内pH值。Ca2+和H+在连接电导的生理调节中的确切作用仍不清楚。文中提出了环磷酸腺苷（cAMP）-钙假说。根据这一观点，cAMP通过特定激酶调节连接通透性。钙和cAMP之间的反馈机制可能与连接电导的生理控制有关。

相似文献

1
Modulation of junctional permeability.连接通透性的调节。
Fed Proc. 1984 Sep;43(12):2692-6.
2
The role of cAMP and Ca on the modulation of junctional conductance: an integrated hypothesis.环磷酸腺苷（cAMP）和钙离子（Ca）在调节连接电导中的作用：一个综合假说。
Cell Biol Int Rep. 1983 Dec;7(12):1033-40. doi: 10.1016/0309-1651(83)90008-5.
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The cell-to-cell channel.细胞间通道。
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