Sussex Eye Hospital, Brighton & Sussex University Hospitals NHS Trust, Eastern Road, Brighton, BN2 5BF, UK.
Medical Faculty, Otto-von-Guericke-University Magdeburg, 39120, Magdeburg, Germany.
Eye (Lond). 2019 May;33(5):804-811. doi: 10.1038/s41433-018-0327-5. Epub 2019 Jan 2.
To assess the effect of peripheral corneal relaxing incisions (PCRI) for astigmatism between 0.75 and 2.5 dioptres during cataract surgery on corneal densitometry (CD).
In this prospective, randomised study, 80 eyes (80 patients), received either tIOL or PCRI. Assessment at pre-operative and 1, 3, 6, 12 months post-operative visit included uncorrected (UCDVA) and best-corrected distance visual acuity (BCDVA), spherical equivalent (SEQ) (only post-operatively), mean anterior and posterior keratometric astigmatism (K) and CD with Schiempflug system. CD was analysed in four concentric radial zones from centre to periphery (Zone 1 to 4) and in 3 layers (anterior, mid-stromal and posterior).
Comparing tIOLs vs. PCRIs, there was no significant difference in the UCDVA, BCDVA and SEQ. In PCRI group, anterior K decreased at 1 month and remained stable thereafter. For zones 1, 2 and 3, CD significantly reduced after 3 months with tIOLs whereas with PCRIs, it reduced 1 month onwards. For zone 4, CD reduced only at 12 months with tIOLs compared to 3 months onwards with PCRIs. In both groups CD was higher in the zone 4 and anterior layer. Significant reduction in CD was found in all three layers of cornea after 3 months in tIOL and after first month in PCRI groups, respectively.
Cataract surgery alone reduces the CD. Reducing keratometric astigmatism with PCRIs shows significant differences in CD from early post-operative period for central and anterior corneal layer.
评估白内障手术中治疗 0.75 至 2.5 屈光度散光的周边角膜松解切口(PCRI)对角膜密度(CD)的影响。
在这项前瞻性、随机研究中,80 只眼(80 例患者)接受了 IOL 或 PCRI。术前及术后 1、3、6、12 个月的评估包括未矫正(UCDVA)和最佳矫正距离视力(BCDVA)、等效球镜(SEQ)(仅术后)、平均前和后角膜散光(K)和用 Scheimpflug 系统测量的 CD。CD 分析从中央到周边分为四个同心辐射区(区 1 至 4)和 3 层(前、中基质和后)。
与 IOL 相比,PCRI 组的 UCDVA、BCVA 和 SEQ 无显著差异。在 PCRI 组中,前 K 在 1 个月时下降,此后保持稳定。对于区域 1、2 和 3,用 IOL 治疗后 3 个月 CD 显著降低,而用 PCRI 治疗后 1 个月 CD 降低。对于区域 4,与 PCRI 治疗后 3 个月相比,IOL 治疗后仅在 12 个月时 CD 降低。在两组中,CD 在区域 4 和前层中较高。在 IOL 组中,3 个月后所有三层角膜的 CD 均显著降低,而在 PCRI 组中,1 个月后 CD 开始降低。
白内障手术本身会降低 CD。用 PCRIs 降低角膜散光可使中央和前角膜层的 CD 在术后早期出现显著差异。