Tavakoli Javad
Medical Device Research Institute, School of Computer Science, Engineering and Mathematics, Flinders University, Adelaide, SA 5042 Australia.
Tissue Eng Regen Med. 2017 Mar 8;14(2):81-91. doi: 10.1007/s13770-017-0024-7. eCollection 2017 Apr.
Tissue engineering as a high technology solution for treating disc's problem has been the focus of some researches recently; however, the upcoming successful results in this area depends on understanding the complexities of biology and engineering interface. Whereas the major responsibility of the nucleus pulposus is to provide a sustainable hydrated environment within the disc, the function of the annulus fibrosus (AF) is more mechanical, facilitating joint mobility and preventing radial bulging by confining of the central part, which makes the AF reconstruction important. Although the body of knowledge regarding the AF tissue engineering has grown rapidly, the opportunities to improve current understanding of how artificial scaffolds are able to mimic the AF concentric structure-including inter-lamellar matrix and cross-bridges-addressed unresolved research questions. The aim of this literature review was to collect and discuss, from the international scientific literature, information about tissue engineering of the AF based on scaffold fabrication and material properties, useful for developing new strategies in disc tissue engineering. The key parameter of this research was understanding if role of cross-bridges and inter-lamellar matrix has been considered on tissue engineering of the AF.
组织工程作为治疗椎间盘问题的高科技解决方案，近来一直是一些研究的焦点；然而，该领域即将取得的成功成果取决于对生物学与工程学界面复杂性的理解。髓核的主要职责是在椎间盘中提供可持续的水合环境，而纤维环（AF）的功能则更具机械性，它通过限制中央部分来促进关节活动并防止径向膨出，这使得纤维环重建变得重要。尽管关于纤维环组织工程的知识体系发展迅速，但在如何改进当前对人工支架能够模拟纤维环同心结构（包括层间基质和交叉桥）的理解方面仍存在未解决的研究问题。这篇文献综述的目的是从国际科学文献中收集并讨论有关基于支架制造和材料特性的纤维环组织工程的信息，这对于开发椎间盘组织工程的新策略很有用。这项研究的关键参数是了解在纤维环组织工程中是否考虑了交叉桥和层间基质的作用。
