Antinori Andrea, Di Biagio Antonio, Marcotullio Simone, Sarmati Loredana, Andreoni Massimo, Angarano Gioacchino, Chirianni Antonio, d'Arminio Monforte Antonella, Di Perri Giovanni, Galli Massimo, Gianotti Nicola, Girardi Enrico, Gori Andrea, Mussini Cristina, Perno Carlo-Federico, Lazzarin Adriano
National Institute for Infectious Diseases L. Spallanzani, IRCCS, Rome, Italy.
Policlinico San Martino Hospital, IRCCS for Cancer Research Genova, Italy.
New Microbiol. 2018 Oct;41(4):247-255.
The Italian Society for Infectious and Tropical Diseases (SIMIT) in collaboration with the Technical Health Committee (Sections L and M) of the Italian Ministry of Health have supported the renewal of the recommendations for the Italian guidelines for the use of antiretroviral agents and the diagnostic-clinical management of HIV-1 infected persons. This publication summarizes the latest updates to the 2017 version of the Italian Guidelines for the management of HIV-1 infected patients and the use of antiretroviral drugs. New recommendations were released framing the clinical questions the use of antiretrovirals according to the Patient Intervention Comparator Outcome (PICO) methodology and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system. Diagnostic tools for immunological and virological monitoring, when to start, what to start, optimization and therapeutic failure were updated in order to include the recommendation obtained with these newly developed methods. For a complete review of clinical and therapeutic relevant topics we refer the reader to the extended version of the Guidelines.
意大利传染病与热带病学会（SIMIT）与意大利卫生部技术卫生委员会（L和M部门）合作，支持更新意大利抗逆转录病毒药物使用指南以及HIV-1感染者的诊断-临床管理建议。本出版物总结了2017年版意大利HIV-1感染患者管理及抗逆转录病毒药物使用指南的最新更新内容。根据患者干预对照结局（PICO）方法和推荐分级评估、制定与评价（GRADE）系统，发布了关于抗逆转录病毒药物使用临床问题的新建议。免疫和病毒学监测的诊断工具、何时开始治疗、使用何种药物、优化治疗以及治疗失败等方面均进行了更新，以纳入通过这些新开发方法获得的建议。如需全面回顾临床和治疗相关主题，我们建议读者参考指南的扩展版本。
