Chronic Kidney Disease Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Weill Cornell Medicine Qatar, Doha, Qatar.
J Cell Physiol. 2019 Aug;234(8):12385-12392. doi: 10.1002/jcp.28066. Epub 2019 Jan 3.
Insulin resistance is a key feature of Type 2 diabetes and an important therapeutic target to address glycemic control to prevent diabetic complications. Lifestyle advice is the first step in the ADA/EASD consensus guidelines followed by metformin therapy. Aerobic exercise (AE) can increase insulin sensitivity by several molecular pathways including upregulation of insulin transporters in the cellular membrane of insulin-dependent cells. In addition, AE improves insulin sensitivity by amelioration of the pathophysiologic pathways involved in insulin resistance such as the reduction of adipokines, inflammatory and oxidative stress responses, and improvement of insulin signal transduction via different molecular pathways. This review details the molecular pathways by which AE induces beneficial effects on insulin resistance.
胰岛素抵抗是 2 型糖尿病的一个关键特征，也是控制血糖以预防糖尿病并发症的重要治疗靶点。ADA/EASD 共识指南建议首先进行生活方式建议，然后再进行二甲双胍治疗。有氧运动 (AE) 可以通过多种分子途径增加胰岛素敏感性，包括上调胰岛素依赖性细胞细胞膜中的胰岛素转运体。此外，AE 通过改善与胰岛素抵抗相关的病理生理途径，如减少脂肪细胞因子、炎症和氧化应激反应，以及通过不同的分子途径改善胰岛素信号转导，来提高胰岛素敏感性。这篇综述详细介绍了 AE 诱导胰岛素抵抗有益作用的分子途径。
