Materials Science and Engineering , University of Colorado , Boulder , Colorado 80309 , United States.
ACS Appl Mater Interfaces. 2019 Jan 16;11(2):1760-1765. doi: 10.1021/acsami.8b21058. Epub 2019 Jan 4.
Antibacterial strategies sans antibiotic drugs have recently garnered much interest as a mechanism by which to inhibit biofilm formation and growth on surfaces due to the rise of antibiotic-resistant bacteria. Based on the photofluidization of azobenzenes, we demonstrate for the first time the ability achieve up to a 4 log reduction in bacterial biofilms by opto-mechanically activating the disruption and dispersion of biofilms. This unique strategy with which to enable biofilm removal offers a novel paradigm with which to combat antibiotic resistance.
由于抗生素耐药菌的出现，抗菌策略（不使用抗生素药物）最近作为一种抑制表面生物膜形成和生长的机制引起了广泛关注。基于偶氮苯的光流态化，我们首次证明了通过光机械激活生物膜的破坏和分散，可实现高达 4 个对数减少细菌生物膜的能力。这种能够实现生物膜去除的独特策略提供了一种对抗抗生素耐药性的新范例。
