Aschhoff M, Raj P P, Lilly L, Srinivasan H
St. Thomas Hospital and Leprosy Centre, Chettupattu, Tamil Nadu.
Indian J Lepr. 1988 Jan;60(1):34-46.
The occurrence of secondary and primary dapsone resistance in 199 patients in our control area and the influence of certain variables such as age, initial bacteriological and morphological indices, duration of regular dapsone monotherapy, on the emergence of dapsone resistance was investigated. Ninety one of 122 patients and 29 out of 77 showed secondary (SDR) and primary (PDR) resistance to dapsone respectively. Very low BI (BI:2.5) group also showed both SDR (60%) and PDR (40%). Low or high MI group exhibited the same degree of resistance. Multiplication of M. leprae was obtained even when the MI of the inocula was zero. Even in the group who had 1 to 5 years duration of regular dapsone treatment, 85% patients showed SDR. Significance of such results are discussed in relation to chemotherapy. The overall minimum prevalence of SDR was found to be 5.6% and 21% in the case of PDR in our control area.
对我们控制区域内199例患者中继发性和原发性氨苯砜耐药的发生情况，以及年龄、初始细菌学和形态学指标、常规氨苯砜单药治疗持续时间等某些变量对氨苯砜耐药出现的影响进行了研究。122例患者中的91例和77例中的29例分别表现出对氨苯砜的继发性（SDR）和原发性（PDR）耐药。极低细菌指数（BI：2.5）组也同时表现出SDR（60%）和PDR（40%）。低或高形态指数（MI）组表现出相同程度的耐药性。即使接种物的MI为零，也能观察到麻风杆菌的增殖。即使在接受常规氨苯砜治疗1至5年的组中，85%的患者表现出SDR。结合化疗对这些结果的意义进行了讨论。在我们的控制区域，SDR的总体最低患病率为5.6%，PDR为21%。
