The Key Laboratory of Protein Chemistry and Developmental Biology of Ministry of Education, College of Life Sciences, Hunan Normal University, Changsha, 410081, China.
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou, 310003, China.
Stem Cell Res Ther. 2019 Jan 3;10(1):1. doi: 10.1186/s13287-018-1105-9.
Menstrual blood-derived stem cells (MenSCs) are a novel source of mesenchymal stem cells (MSCs). MenSCs are attracting more and more attention since their discovery in 2007. MenSCs also have no moral dilemma and show some unique features of known adult-derived stem cells, which provide an alternative source for the research and application in regenerative medicine. Currently, people are increasingly interested in their clinical potential due to their high proliferation, remarkable versatility, and periodic acquisition in a non-invasive manner with no other sources of MSCs that are comparable in adult tissue. In this review, the plasticity of pluripotent biological characteristics, immunophenotype and function, differentiative potential, and immunomodulatory properties are assessed. Furthermore, we also summarize their therapeutic effects and functional characteristics in various diseases, including liver disease, diabetes, stroke, Duchenne muscular dystrophy, ovarian-related disease, myocardial infarction, Asherman syndrome, Alzheimer's disease, acute lung injury, cutaneous wound, endometriosis, and neurodegenerative diseases. Subsequently, the clinical potential of MenSCs is investigated. There is a need for a deeper understanding of its immunomodulatory and diagnostic properties with safety concern on a variety of environmental conditions (such as epidemiological backgrounds, age, hormonal status, and pre-contraceptive). In summary, MenSC has a great potential for reducing mortality and improving the quality of life of severe patients. As a kind of adult stem cells, MenSCs have multiple properties in treating a variety of diseases in regenerative medicine for future clinical applications.
经血来源的干细胞（MenSCs）是间充质干细胞（MSCs）的一种新来源。自 2007 年发现以来，MenSCs 引起了越来越多的关注。MenSCs 也没有道德困境，并且表现出一些已知的成体来源干细胞的独特特征，为再生医学的研究和应用提供了替代来源。目前，由于其高增殖性、显著的多功能性以及以非侵入性方式定期获得，而没有其他来源的 MSC 可以与成人组织相媲美，因此人们对其临床潜力越来越感兴趣。在这篇综述中，评估了多能生物特性、免疫表型和功能、分化潜能和免疫调节特性的可塑性。此外，我们还总结了它们在各种疾病中的治疗效果和功能特征，包括肝病、糖尿病、中风、杜氏肌营养不良症、卵巢相关疾病、心肌梗死、Asherman 综合征、阿尔茨海默病、急性肺损伤、皮肤伤口、子宫内膜异位症和神经退行性疾病。随后，研究了 MenSCs 的临床潜力。需要更深入地了解其免疫调节和诊断特性，并关注各种环境条件（如流行病学背景、年龄、激素状态和避孕前）下的安全性。总之，MenSC 具有降低严重患者死亡率和提高生活质量的巨大潜力。作为一种成体干细胞，MenSCs 在再生医学中具有多种特性，可以治疗多种疾病，具有未来的临床应用前景。
