State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310003, People's Republic of China.
Department of Respiratory Disease, Thoracic Disease Centre, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310003, People's Republic of China.
Stem Cell Res Ther. 2021 Aug 3;12(1):433. doi: 10.1186/s13287-021-02511-6.
Menstrual blood-derived mesenchymal stem cells (MenSCs) have great potential in regenerative medicine. MenSC has received increasing attention owing to its impressive therapeutic effects in both preclinical and clinical trials. However, the study of MenSC-derived small extracellular vesicles (EVs) is still in its initial stages, in contrast to some common MSC sources (e.g., bone marrow, umbilical cord, and adipose tissue). We describe the basic characteristics and biological functions of MenSC-derived small EVs. We also demonstrate the therapeutic potential of small EVs in fulminant hepatic failure, myocardial infarction, pulmonary fibrosis, prostate cancer, cutaneous wound, type-1 diabetes mellitus, aged fertility, and potential diseases. Subsequently, novel hotspots with respect to MenSC EV-based therapy are proposed to overcome current challenges. While complexities regarding the therapeutic potential of MenSC EVs continue to be unraveled, advances are rapidly emerging in both basic science and clinical medicine. MenSC EV-based treatment has great potential for treating a series of diseases as a novel therapeutic strategy in regenerative medicine.
经血来源间充质干细胞（MenSCs）在再生医学中有巨大的潜力。MenSC 因其在临床前和临床试验中令人印象深刻的治疗效果而受到越来越多的关注。然而，与一些常见的 MSC 来源（如骨髓、脐带和脂肪组织）相比，MenSC 衍生的小细胞外囊泡（EVs）的研究仍处于起步阶段。我们描述了 MenSC 衍生的小 EVs 的基本特征和生物学功能。我们还展示了小 EVs 在暴发性肝衰竭、心肌梗死、肺纤维化、前列腺癌、皮肤创伤、1 型糖尿病、老年生育能力和潜在疾病中的治疗潜力。随后，提出了基于 MenSC EV 治疗的新热点，以克服当前的挑战。虽然 MenSC EV 治疗潜力的复杂性仍在不断揭示，但基础科学和临床医学都在迅速发展。基于 MenSC EV 的治疗作为再生医学中的一种新的治疗策略，具有治疗一系列疾病的巨大潜力。
