Suriyaprom Kanjana, Kaewprasert Sarunya, Putpadungwipon Pumpath, Namjuntra Pisit, Klongthalay Suwit
Faculty of Medical Technology, Rangsit University, Paholyothin Road, Pathumthani, 12000, Thailand.
Department of Tropical Nutrition and Food Science, Faculty of Tropical Medicine, Mahidol University, 420/6 Rajvithi Road, Rajthevee, Bangkok, 10400, Thailand.
J Health Popul Nutr. 2019 Jan 3;38(1):1. doi: 10.1186/s41043-018-0158-9.
An oxidant/antioxidant disequilibrium has been suggested as having a role in the pathogenesis of some diseases. Metabolic syndrome (MS) is significantly associated with cardiovascular disease and type 2 diabetes. The pathogenesis of MS is complex and not well understood. The purposes of the present study were to compare enzymatic and non-enzyme antioxidants, anthropometric, hematological, and biochemical findings between subjects with MS and without MS and to evaluate the relationship between antioxidant status and hematological parameters with the components of MS.
Metabolic syndrome was assessed by using the modified National Cholesterol Education Program, Adult Treatment Panel III criteria. Three hundred Thais, 124 with MS and 176 without MS, were included in the study. Each subject was tested for erythrocyte superoxide dismutase (SOD), glutathione peroxidase, (GPX), catalase (CAT), albumin and vitamin C levels, and hematological findings.
Subjects with MS had lower SOD and CAT levels than those without MS (p < 0.01). Subjects with MS had lower vitamin C and albumin levels than those without MS (p < 0.05). The hematological findings were not significantly different between those with and without MS except the white blood cell (WBC) count which was significantly higher in those with MS. SOD and CAT levels were significantly positively associated with HDL-C levels and negatively associated with components of MS. After adjusting for potential covariates, we found lower SOD and vitamin C levels and higher WBC counts were significantly associated with MS (p < 0.05).
These findings suggest an alteration in antioxidant status and an increase in inflammatory markers are associated with MS and its components among Thais; subjects with MS may be more likely to have oxidative stress problems.
氧化/抗氧化失衡被认为在某些疾病的发病机制中起作用。代谢综合征（MS）与心血管疾病和2型糖尿病显著相关。MS的发病机制复杂，尚未完全了解。本研究的目的是比较MS患者和非MS患者的酶促和非酶促抗氧化剂、人体测量学、血液学和生化指标，并评估抗氧化状态和血液学参数与MS各组分之间的关系。
采用改良的美国国家胆固醇教育计划成人治疗小组第三次报告标准评估代谢综合征。300名泰国人参与了研究，其中124人患有MS，176人未患MS。对每位受试者进行红细胞超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GPX）、过氧化氢酶（CAT）、白蛋白和维生素C水平以及血液学指标检测。
MS患者的SOD和CAT水平低于非MS患者（p<0.01）。MS患者的维生素C和白蛋白水平低于非MS患者（p<0.05）。除白细胞（WBC）计数外，MS患者和非MS患者的血液学指标无显著差异，MS患者的WBC计数显著更高。SOD和CAT水平与高密度脂蛋白胆固醇（HDL-C）水平显著正相关，与MS各组分负相关。在对潜在协变量进行调整后，我们发现较低的SOD和维生素C水平以及较高的WBC计数与MS显著相关（p<0.05）。
这些发现表明，泰国人中抗氧化状态的改变和炎症标志物的增加与MS及其组分相关；MS患者可能更易出现氧化应激问题。
