乳腺癌免疫治疗疫苗研发的当前方法
Current Approaches in Development of Immunotherapeutic Vaccines for Breast Cancer.
作者信息
Allahverdiyev Adil, Tari Gamze, Bagirova Melahat, Abamor Emrah Sefik
机构信息
Department of Bioengineering, Faculty of Chemical and Metallurgical Engineering, Yildiz Technical University, Istanbul, Turkey.
出版信息
J Breast Cancer. 2018 Dec;21(4):343-353. doi: 10.4048/jbc.2018.21.e47. Epub 2018 Oct 29.
Abstract
Cancer is the leading cause of death worldwide. In developed as well as developing countries, breast cancer is the most common cancer found among women. Currently, treatment of breast cancer consists mainly of surgery, chemotherapy, hormone therapy, and radiotherapy. In recent years, because of increased understanding of the therapeutic potential of immunotherapy in cancer prevention, cancer vaccines have gained importance. Here, we review various immunotherapeutic breast cancer vaccines including peptide-based vaccines, whole tumor cell vaccines, gene-based vaccines, and dendritic cell vaccines. We also discuss novel nanotechnology-based approaches to improving breast cancer vaccine efficiency.
摘要
癌症是全球主要的死亡原因。在发达国家和发展中国家，乳腺癌都是女性中最常见的癌症。目前，乳腺癌的治疗主要包括手术、化疗、激素疗法和放射疗法。近年来，由于对免疫疗法在癌症预防中的治疗潜力有了更多了解，癌症疫苗变得越发重要。在此，我们综述了各种免疫治疗性乳腺癌疫苗，包括基于肽的疫苗、全肿瘤细胞疫苗、基于基因的疫苗和树突状细胞疫苗。我们还讨论了基于纳米技术的新型方法，以提高乳腺癌疫苗的效率。
相似文献
1
Current Approaches in Development of Immunotherapeutic Vaccines for Breast Cancer.乳腺癌免疫治疗疫苗研发的当前方法
J Breast Cancer. 2018 Dec;21(4):343-353. doi: 10.4048/jbc.2018.21.e47. Epub 2018 Oct 29.
2
Cancer vaccines as a targeted immunotherapy approach for breast cancer: an update of clinical evidence.癌症疫苗作为一种针对乳腺癌的靶向免疫治疗方法：临床证据的更新。
Expert Rev Vaccines. 2022 Mar;21(3):337-353. doi: 10.1080/14760584.2022.2021884. Epub 2022 Jan 6.
3
Therapeutic breast cancer vaccines: a new strategy for early-stage disease.治疗性乳腺癌疫苗：早期疾病的新策略。
BioDrugs. 2009;23(5):277-87. doi: 10.2165/11313490-000000000-00000.
4
New Immunotherapy Strategies in Breast Cancer.乳腺癌的新型免疫治疗策略
Int J Environ Res Public Health. 2017 Jan 12;14(1):68. doi: 10.3390/ijerph14010068.
5
Immunotherapy for the treatment of breast cancer.用于治疗乳腺癌的免疫疗法。
Expert Opin Biol Ther. 2017 Jul;17(7):797-812. doi: 10.1080/14712598.2017.1324566. Epub 2017 May 8.
6
Progress in Vaccine Therapies for Breast Cancer.疫苗疗法在乳腺癌治疗中的进展。
Adv Exp Med Biol. 2017;1026:315-330. doi: 10.1007/978-981-10-6020-5_15.
7
Immunotherapeutic approaches for the treatment of breast cancer.用于治疗乳腺癌的免疫治疗方法。
J Mammary Gland Biol Neoplasia. 1999 Oct;4(4):353-65. doi: 10.1023/a:1018714300217.
8
Phenotypic profile of dendritic and T cells in the lymph node of Balb/C mice with breast cancer submitted to dendritic cells immunotherapy.接受树突状细胞免疫治疗的乳腺癌Balb/C小鼠淋巴结中树突状细胞和T细胞的表型特征
Immunol Lett. 2016 Sep;177:25-37. doi: 10.1016/j.imlet.2016.07.009. Epub 2016 Jul 14.
9
Immunotherapy in breast cancer: Current status and future directions.乳腺癌的免疫治疗：现状与未来方向。
Adv Cancer Res. 2019;143:295-349. doi: 10.1016/bs.acr.2019.03.006. Epub 2019 May 2.
10
MUC1-based recombinant Bacillus Calmette-Guerin vaccines as candidates for breast cancer immunotherapy.基于 MUC1 的重组卡介苗疫苗作为乳腺癌免疫治疗的候选物。
Expert Opin Biol Ther. 2010 Jul;10(7):1037-48. doi: 10.1517/14712598.2010.485185.
引用本文的文献
1
An Investigation of the Met1915Thr Polymorphism in Azerbaijani Breast Cancer Patients.阿塞拜疆乳腺癌患者中Met1915Thr多态性的调查。
Med Sci (Basel). 2025 Jul 31;13(3):103. doi: 10.3390/medsci13030103.
2
Oxidized Mannan: A Novel Adjuvant Candidate for Enhancing Immune Responses in Veterinary Rabies Vaccine.氧化甘露聚糖：一种用于增强兽用狂犬病疫苗免疫反应的新型佐剂候选物。
Chonnam Med J. 2025 May;61(2):84-89. doi: 10.4068/cmj.2025.61.2.84. Epub 2025 May 23.
3
Personalized neoantigen cancer vaccines: current progression, challenges and a bright future.个性化新抗原癌症疫苗：当前进展、挑战与光明前景。
Clin Exp Med. 2024 Sep 26;24(1):229. doi: 10.1007/s10238-024-01436-7.
4
Spatial and Temporal Mapping of Breast Cancer Lung Metastases Identify TREM2 Macrophages as Regulators of the Metastatic Boundary.乳腺癌肺转移的时空图谱确定TREM2巨噬细胞为转移边界的调节因子。
Cancer Discov. 2023 Dec 12;13(12):2610-2631. doi: 10.1158/2159-8290.CD-23-0299.
5
Crosstalk between Gut Microbiota and Host Immunity: Impact on Inflammation and Immunotherapy.肠道微生物群与宿主免疫之间的相互作用：对炎症和免疫治疗的影响
Biomedicines. 2023 Jan 20;11(2):294. doi: 10.3390/biomedicines11020294.
6
Gut Microbiota and Immunotherapy.肠道微生物群与免疫疗法
Front Microbiol. 2022 Jul 1;13:945887. doi: 10.3389/fmicb.2022.945887. eCollection 2022.
7
Intercepting Premalignant, Preinvasive Breast Lesions Through Vaccination.通过疫苗接种阻断癌前、癌前浸润性乳腺病变。
Front Immunol. 2021 Nov 24;12:786286. doi: 10.3389/fimmu.2021.786286. eCollection 2021.
8
Advancements in Human Breast Cancer Targeted Therapy and Immunotherapy.人类乳腺癌靶向治疗与免疫治疗的进展
J Cancer. 2021 Oct 11;12(23):6949-6963. doi: 10.7150/jca.64205. eCollection 2021.
9
Current and Future Therapies for Immunogenic Cell Death and Related Molecules to Potentially Cure Primary Breast Cancer.免疫原性细胞死亡及相关分子治疗原发性乳腺癌的现状与未来疗法
Cancers (Basel). 2021 Sep 23;13(19):4756. doi: 10.3390/cancers13194756.
10
From Conventional to Precision Therapy in Canine Mammary Cancer: A Comprehensive Review.从犬类乳腺癌的传统治疗到精准治疗：全面综述
Front Vet Sci. 2021 Feb 17;8:623800. doi: 10.3389/fvets.2021.623800. eCollection 2021.
本文引用的文献
1
Autologous tumor cells/bacillus Calmette-Guérin/formalin-based novel breast cancer vaccine induces an immune antitumor response.自体肿瘤细胞/卡介苗/基于福尔马林的新型乳腺癌疫苗可诱导免疫抗肿瘤反应。
Oncotarget. 2018 Apr 17;9(29):20222-20238. doi: 10.18632/oncotarget.25044.
2
Virus-like particle display of HER2 induces potent anti-cancer responses.HER2的病毒样颗粒展示诱导强烈的抗癌反应。
Oncoimmunology. 2018 Jan 5;7(3):e1408749. doi: 10.1080/2162402X.2017.1408749. eCollection 2018.
3
A Virus-Like-Particle immunotherapy targeting Epitope-Specific anti-xCT expressed on cancer stem cell inhibits the progression of metastatic cancer .一种靶向癌症干细胞上表达的表位特异性抗xCT的病毒样颗粒免疫疗法可抑制转移性癌症的进展。
Oncoimmunology. 2017 Dec 6;7(3):e1408746. doi: 10.1080/2162402X.2017.1408746. eCollection 2018.
4
Combination Immunotherapy of MUC1 mRNA Nano-vaccine and CTLA-4 Blockade Effectively Inhibits Growth of Triple Negative Breast Cancer.MUC1 mRNA 纳米疫苗联合 CTLA-4 阻断的免疫治疗有效抑制三阴性乳腺癌的生长。
Mol Ther. 2018 Jan 3;26(1):45-55. doi: 10.1016/j.ymthe.2017.10.020. Epub 2017 Dec 5.
5
Targeting tumor-associated carbohydrate antigens: a phase I study of a carbohydrate mimetic-peptide vaccine in stage IV breast cancer subjects.靶向肿瘤相关碳水化合物抗原：一项针对IV期乳腺癌患者的碳水化合物模拟肽疫苗的I期研究。
Oncotarget. 2017 Oct 23;8(58):99161-99178. doi: 10.18632/oncotarget.21959. eCollection 2017 Nov 17.
6
A pilot study of the immunogenicity of a 9-peptide breast cancer vaccine plus poly-ICLC in early stage breast cancer.一项初步研究显示，在早期乳腺癌患者中，一种 9 肽乳腺癌疫苗联合聚肌胞苷酸（poly-ICLC）具有免疫原性。
J Immunother Cancer. 2017 Nov 21;5(1):92. doi: 10.1186/s40425-017-0295-5.
7
Conjugated nanoliposome with the HER2/neu-derived peptide GP2 as an effective vaccine against breast cancer in mice xenograft model.载 HER2/neu 衍生肽 GP2 的共轭纳米脂质体作为一种有效的针对乳腺癌的疫苗在小鼠异种移植模型中的应用。
PLoS One. 2017 Oct 18;12(10):e0185099. doi: 10.1371/journal.pone.0185099. eCollection 2017.
8
A nano-liposome vaccine carrying E75, a HER-2/neu-derived peptide, exhibits significant antitumour activity in mice.携带 E75（一种 HER-2/neu 衍生肽）的纳米脂质体疫苗在小鼠中表现出显著的抗肿瘤活性。
J Drug Target. 2018 Apr;26(4):365-372. doi: 10.1080/1061186X.2017.1387788. Epub 2017 Oct 18.
9
Toward Personalized Peptide-Based Cancer Nanovaccines: A Facile and Versatile Synthetic Approach.迈向基于个性化肽的癌症纳米疫苗：一种简便通用的合成方法。
Bioconjug Chem. 2017 Nov 15;28(11):2756-2771. doi: 10.1021/acs.bioconjchem.7b00502. Epub 2017 Oct 13.
10
GK-1 peptide reduces tumor growth, decreases metastatic burden, and increases survival in a murine breast cancer model.GK-1肽可降低小鼠乳腺癌模型中的肿瘤生长、减轻转移负担并提高生存率。
Vaccine. 2017 Oct 9;35(42):5653-5661. doi: 10.1016/j.vaccine.2017.08.060. Epub 2017 Sep 7.
Zotero 插件