Zeng Shaoxue, Liang Chen, He Yueqing, Chen Yingying, Zhao Qing, Dai Shuiping, Cheng Fengrui, Zhang Junjun, Jiang Xiaoshuang
Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu 610041, China.
West China School of Medicine, Sichuan University, Chengdu 610041, China.
J Ophthalmol. 2018 Nov 12;2018:2501325. doi: 10.1155/2018/2501325. eCollection 2018.
To investigate the effect of cataract surgery on subfoveal choroid thickness (SFCT) using enhanced-depth imaging optical coherence tomography (EDI-OCT).
Relevant publications were searched systematically through various databases from inception to March 2018. The unit of choroidal thickness measurements is micrometers. Studies comparing SFCT before and after cataract surgery were retrieved. All qualified articles were analyzed using RevMan 5.3.
A total of 13 studies with 802 eyes from 646 patients were identified for inclusion. There was a significant increase of SFCT at 1 week (MD = 6.62, 95% CI: 1.20-12.05, =0.02, I = 0%), 1 month (MD = 8.30, 95% CI: 3.20-13.39, =0.001, I = 0%), and 3 months (MD = 8.28, 95% CI: 1.84-14.73, =0.01, I = 0%) after cataract surgery. In subgroup analysis, SFCT in Asians and patients without nonsteroidal anti-inflammatory drugs (NSAIDs) in postoperative medication was significantly thicker ( < 0.05). No statistically significant increase of SFCT was found in diabetic mellitus (DM) patients for 1 day (=0.89), 1 week (=0.59), 1 month (=0.52), and 3 months (=0.42) after cataract surgery.
This meta-analysis suggested that SFCT increased since 1 week after the cataract surgery and the increase lasted for at least 3 months. Asians and patients without NSAIDs in postoperative medication were more likely to have a thicker SFCT after cataract surgery, whereas DM patients were less likely to increase in SFCT.
使用增强深度成像光学相干断层扫描（EDI-OCT）研究白内障手术对黄斑中心凹下脉络膜厚度（SFCT）的影响。
从数据库建立至2018年3月系统检索相关出版物。脉络膜厚度测量单位为微米。检索比较白内障手术前后SFCT的研究。所有合格文章使用RevMan 5.3进行分析。
共纳入13项研究，涉及646例患者的802只眼。白内障手术后1周（MD = 6.62，95%CI：1.20 - 12.05，P = 0.02，I² = 0%）、1个月（MD = 8.30，95%CI：3.20 - 13.39，P = 0.001，I² = 0%）和3个月（MD = 8.28，95%CI：1.84 - 14.73，P = 0.01，I² = 0%）时SFCT显著增加。亚组分析中，亚洲人和术后用药未使用非甾体抗炎药（NSAIDs）的患者SFCT显著增厚（P < 0.05）。白内障手术后1天（P = 0.89）、1周（P = 0.59）、1个月（P = 0.52）和3个月（P = 0.42）时，糖尿病（DM）患者的SFCT未发现有统计学意义的增加。
这项荟萃分析表明，白内障手术后1周起SFCT增加，且这种增加持续至少3个月。亚洲人和术后用药未使用NSAIDs的患者白内障手术后SFCT更可能增厚，而DM患者SFCT增加的可能性较小。
