Department of Food Science and Engineering, College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen, Guangdong, People's Republic of China.
Key Laboratory of Optoelectronic Devices and System of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen, 518060, People's Republic of China.
Appl Microbiol Biotechnol. 2019 Feb;103(4):1557-1571. doi: 10.1007/s00253-018-9550-z. Epub 2019 Jan 3.
Chitosan is a naturally occurring biodegradable as well as a non-toxic polymer generated from chitin through alkaline deacetylation reaction, and it is insoluble in organic/inorganic solvents and water. Furthermore, chitosan is one of the most plentiful cationic polymers in natural surroundings. Due to its non-toxicity and biocompatibility, chitosan is extensively employed in industrial, biomedical, food, pharmaceutical, environmental, and agricultural industry. Chitosan-based biomaterials exhibit great potential in various biotechnological applications, such as anti-hypertensive therapy, anti-oxidant, anti-microbial, anti-allergic, immunostimulant, cancer therapy, delivery of genetic materials, delivery of bone morphogenetic type-2, wound healing, treatment of wastewater, hypocholesterolemic, and bio-imaging. Therefore, this review mainly focuses on the biotechnological potential of chitosan and its derivatives as well as presents the potential of chitosan-based biomaterial/pharmaceutical for the prevention of various life-threating chronic disorders.
壳聚糖是一种天然存在的可生物降解且无毒的聚合物，通过碱性脱乙酰反应从几丁质中生成，不溶于有机/无机溶剂和水。此外，壳聚糖是天然环境中最丰富的阳离子聚合物之一。由于其无毒和生物相容性，壳聚糖被广泛应用于工业、生物医学、食品、制药、环境和农业等行业。基于壳聚糖的生物材料在各种生物技术应用中具有巨大的潜力，如抗高血压治疗、抗氧化、抗菌、抗过敏、免疫刺激、癌症治疗、遗传物质的传递、骨形态发生蛋白 2 的传递、伤口愈合、废水处理、降胆固醇和生物成像。因此，本综述主要关注壳聚糖及其衍生物的生物技术潜力，并介绍基于壳聚糖的生物材料/药物在预防各种威胁生命的慢性疾病方面的潜力。
Zotero 插件