超声引导下经皮微波消融术与内镜甲状腺切除术治疗甲状腺微小乳头状癌患者的疗效差异：系统评价与Meta分析方案
Differences in treatment outcomes between ultrasound-guided percutaneous microwave ablation and endoscopic thyroidectomy for patients with papillary thyroid microcarcinoma: Protocol for a systematic review and meta-analysis.
作者信息
Shen Yan, Liu Miao, He Jie, Wu Shu, Wan Yong-Lin, Ding Jun, Cai Xiao-Yan, Fu Xiao-Hong
机构信息
Department of Medical Ultrasound.
Department of Pathology.
出版信息
Medicine (Baltimore). 2019 Jan;98(1):e13953. doi: 10.1097/MD.0000000000013953.
BACKGROUND
The differences in treatment outcomes between ultrasound (US)-guided percutaneous microwave ablation (PMWA) and endoscopic thyroidectomy for patients with papillary thyroid microcarcinoma (PTMC) remains unknown.
METHODS
An electronic search will be performed for randomized controlled trials or observational studies that reported recurrence and mortality rates in PTMC patients with US-guided PMWA or endoscopic thyroidectomy. Hazard ratios with their 95% confidence intervals will be calculated using fixed- or random-effects models according to heterogeneity.
RESULTS
This study will present the differences in treatment outcomes between US-guided PMWA and endoscopic thyroidectomy for patients with PTMC by pooling the results of individual studies.
CONCLUSION
The results of this study would provide vigorous evidence in this issue and offer the guidance to both clinical decision-making and future research.
ETHICS AND DISSEMINATION
Ethical approval is not applicable for this study.
PROSPERO REGISTRATION NUMBER
CRD42018112320.
背景
对于甲状腺微小乳头状癌（PTMC）患者，超声（US）引导下经皮微波消融（PMWA）与内镜甲状腺切除术的治疗效果差异尚不清楚。
方法
将进行电子检索，以查找报告了接受US引导下PMWA或内镜甲状腺切除术的PTMC患者复发率和死亡率的随机对照试验或观察性研究。将根据异质性使用固定效应或随机效应模型计算风险比及其95%置信区间。
结果
本研究将通过汇总个体研究结果，呈现US引导下PMWA与内镜甲状腺切除术治疗PTMC患者的治疗效果差异。
结论
本研究结果将为该问题提供有力证据，并为临床决策和未来研究提供指导。
伦理与传播
本研究无需伦理批准。
PROSPERO注册号：CRD42018112320。
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