School of Pharmacy and Heath Sciences , Fairleigh Dickinson University , Florham Park , New Jersey 07932 , United States.
Mallinckrodt Institute of Radiology , Washington University School of Medicine , St. Louis , Missouri 63110 , United States.
Mol Pharm. 2019 Feb 4;16(2):552-560. doi: 10.1021/acs.molpharmaceut.8b00836. Epub 2019 Jan 16.
Nanogels are attractive biocompatible materials that enable local delivery of multiple drugs. In this study, we demonstrated that 3D printing technology could be used to precisely construct nanogel discs carrying paclitaxel and rapamycin. 3D-printed nanogel disc rounds (12 mm diameter × 1 mm thickness) carrying paclitaxel and rapamycin evaded premature gelation during storage and the initial burst release of the drugs in the dissolution medium. In vivo 3D-printed nanogel discs permitted successful intraperitoneal delivery of paclitaxel and rapamycin in ES-2-luc ovarian-cancer-bearing xenograft mice. They were also shown to be therapeutically effective and capable of preventing postsurgical peritoneal adhesions in the treated xenograft mice.
纳米凝胶是一种有吸引力的生物相容性材料，能够实现多种药物的局部递送。在这项研究中，我们证明了 3D 打印技术可用于精确构建携带紫杉醇和雷帕霉素的纳米凝胶盘。3D 打印的纳米凝胶盘（直径 12 毫米×厚度 1 毫米）携带紫杉醇和雷帕霉素，可避免在储存过程中过早胶凝和药物在溶解介质中的初始突释。体内 3D 打印纳米凝胶盘可成功递送至携带 ES-2-luc 卵巢癌的异种移植小鼠的腹腔内，递送至腹腔内。研究还表明，它们具有治疗效果，并能够预防治疗性异种移植小鼠的术后腹膜粘连。
