Centre for Perinatal Neuroscience, Imperial College London, London, UK.
Oliver Fisher Neonatal Unit, Medway Maritime Hospital, Kent, UK.
Arch Dis Child Fetal Neonatal Ed. 2018 Jul;103(4):F383-F387. doi: 10.1136/archdischild-2017-313321. Epub 2017 Sep 21.
We examined the brain injury and neurodevelopmental outcomes in a prospective cohort of 10 babies with mild encephalopathy who had early cessation of cooling therapy. All babies had MRI and spectroscopy within 2 weeks after birth and neurodevelopmental assessment at 2 years. Cooling was prematurely discontinued at a median age of 9 hours (IQR 5-13) due to rapid clinical improvement. Five (50%) had injury on MRI or spectroscopy, and two (20%) had an abnormal neurodevelopmental outcome at 2 years. Premature cessation of cooling therapy in babies with mild neonatal encephalopathy does not exclude residual brain injury and adverse long-term neurodevelopmental outcomes. This study refers to babies recruited into the MARBLE study (NCT01309711, pre-results stage).
我们在一项前瞻性队列研究中检查了 10 名轻度脑病婴儿的脑损伤和神经发育结果,这些婴儿在早期停止了冷却治疗。所有婴儿在出生后 2 周内进行 MRI 和光谱检查,并在 2 岁时进行神经发育评估。由于临床迅速改善,冷却在中位数为 9 小时(IQR 5-13)时过早停止。有 5 名(50%)婴儿的 MRI 或光谱显示有损伤,2 名(20%)婴儿在 2 岁时神经发育结果异常。在轻度新生儿脑病婴儿中过早停止冷却治疗并不能排除残留的脑损伤和不良的长期神经发育结果。这项研究指的是 MARBLE 研究(NCT01309711,预结果阶段)中招募的婴儿。