Muir G D, Webb A A
Department of Veterinary Physiological Sciences, University of Saskatchewan, Saskatoon, Canada S7N 5B4.
Eur J Neurosci. 2000 Sep;12(9):3079-86. doi: 10.1046/j.1460-9568.2000.00205.x.
Behavioural recovery is one of the primary goals of therapeutic intervention in animal models of disease. It is necessary, therefore, to have the means with which to quantify pertinent behavioural changes in experimental animals. Nevertheless, the number and diversity of behavioural measures which have been used to assess recovery after experimental interventions often makes it difficult to compare results between studies. The present review attempts to integrate and categorize the wide variety of behavioural assessments used to measure recovery in spinal-injured rats. These categories include endpoint measures, kinematic measures, kinetic measurements, and electrophysiological measurements. Within this categorization, we discuss the advantages and disadvantages of each type of measurement. Finally, we make some recommendations regarding the principles for a comprehensive behavioural analysis after experimental spinal cord injury in rats.
行为恢复是疾病动物模型治疗干预的主要目标之一。因此，有必要具备量化实验动物相关行为变化的方法。然而，用于评估实验干预后恢复情况的行为测量方法的数量和多样性，常常使得不同研究之间的结果难以比较。本综述试图对用于测量脊髓损伤大鼠恢复情况的各种行为评估方法进行整合和分类。这些类别包括终点测量、运动学测量、动力学测量和电生理测量。在这种分类中，我们讨论了每种测量类型的优缺点。最后，我们就大鼠实验性脊髓损伤后进行全面行为分析的原则提出了一些建议。
