Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia; Laboratory of Preclinical Bioscreening, Granov Russian Research Center of Radiology and Surgical Technologies, Ministry of Healthcare of Russian Federation, Pesochny, Russia.
Bioscience Institute, University of Passo Fundo (UPF), Passo Fundo, RS, Brazil; The International Zebrafish Neuroscience Research Consortium (ZNRC), Slidell, LA, USA.
Prog Neuropsychopharmacol Biol Psychiatry. 2019 Jun 8;92:48-58. doi: 10.1016/j.pnpbp.2018.11.016. Epub 2018 Nov 23.
Diabetes mellitus (DM) is a common metabolic disorder that affects multiple organ systems. DM also affects brain processes, contributing to various CNS disorders, including depression, anxiety and Alzheimer's disease. Despite active research in humans, rodent models and in-vitro systems, the pathogenetic link between DM and brain disorders remains poorly understood. Novel translational models and new model organisms are therefore essential to more fully study the impact of DM on CNS. The zebrafish (Danio rerio) is a powerful novel model species to study metabolic and CNS disorders. Here, we discuss how DM alters brain functions and behavior in zebrafish, and summarize their translational relevance to studying DM-related CNS pathogenesis in humans. We recognize the growing utility of zebrafish models in translational DM research, as they continue to improve our understanding of different brain pathologies associated with DM, and may foster the discovery of drugs that prevent or treat these diseases.
糖尿病（DM）是一种常见的代谢紊乱，影响多个器官系统。DM 还会影响大脑过程，导致各种中枢神经系统疾病，包括抑郁症、焦虑症和阿尔茨海默病。尽管在人类、啮齿动物模型和体外系统中进行了积极的研究，但 DM 与大脑疾病之间的发病机制联系仍知之甚少。因此，新型转化模型和新的模式生物对于更全面地研究 DM 对中枢神经系统的影响至关重要。斑马鱼（Danio rerio）是一种强大的新型模式生物，可用于研究代谢和中枢神经系统疾病。在这里，我们讨论了 DM 如何改变斑马鱼的大脑功能和行为，并总结了它们在研究人类 DM 相关中枢神经系统发病机制方面的转化相关性。我们认识到斑马鱼模型在转化 DM 研究中的应用不断增加，因为它们继续加深我们对与 DM 相关的不同大脑病理学的理解，并可能促进预防或治疗这些疾病的药物的发现。
