Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), 335 Science Road, Daejeon 305-701, Republic of Korea.
Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), 335 Science Road, Daejeon 305-701, Republic of Korea.
Curr Opin Chem Biol. 2019 Apr;49:122-129. doi: 10.1016/j.cbpa.2018.12.002. Epub 2019 Jan 3.
Redox biocatalysis has come to the forefront because of its excellent catalytic efficiency, stereoselectivity, and environmental benignity. The green and sustainable biotransformation can be driven by photoelectrochemical (PEC) platforms where redox biocatalysis is coupled with photoelectrocatalysis. The main challenge is how to transfer photoexcited electrons to (or from) the enzyme redox centers for effective biotransformation using solar energy. This review commences with a conceptual discussion of biocatalytic PEC platforms and highlights recent advances in PEC-based biotransformation through cofactor regeneration or direct transfer of charge carriers to (or from) oxidoreductases on enzyme-conjugated electrodes. Finally, we address future perspectives and potential next steps in the vibrant field of biocatalytic photosynthesis.
氧化还原生物催化因其出色的催化效率、立体选择性和环境友好性而成为研究热点。光电化学（PEC）平台可以驱动绿色可持续的生物转化，其中氧化还原生物催化与光电催化相结合。主要的挑战是如何利用太阳能将光激发电子转移到（或从）酶氧化还原中心，以实现有效的生物转化。本综述首先对生物催化 PEC 平台进行了概念性讨论，并重点介绍了通过辅因子再生或直接将电荷载体转移到（或从）酶偶联电极上的氧化还原酶来实现基于 PEC 的生物转化的最新进展。最后，我们讨论了生物催化光合作用这一充满活力的领域的未来展望和潜在的下一步发展方向。
