Groningen Research Institute of Pharmacy, Department of Chemical and Pharmaceutical Biology, Antonius Deusinglaan 1, 9713 AV, Groningen (The, Netherlands.
Chembiochem. 2021 Mar 2;22(5):790-806. doi: 10.1002/cbic.202000587. Epub 2020 Nov 6.
In the field of green chemistry, light - an attractive natural agent - has received particular attention for driving biocatalytic reactions. Moreover, the implementation of light to drive (chemo)enzymatic cascade reactions opens up a golden window of opportunities. However, there are limitations to many current examples, mostly associated with incompatibility between the enzyme and the photocatalyst. Additionally, the formation of reactive radicals upon illumination and the loss of catalytic activities in the presence of required additives are common observations. As outlined in this review, the main question is how to overcome current challenges to the exploitation of light to drive (chemo)enzymatic transformations. First, we highlight general concepts in photo-biocatalysis, then give various examples of photo-chemoenzymatic (PCE) cascades, further summarize current synthetic examples of PCE cascades and discuss strategies to address the limitations.
在绿色化学领域，光——一种有吸引力的自然试剂——因其能驱动生物催化反应而受到特别关注。此外，利用光来驱动（化）酶级联反应为我们提供了一个绝佳的机会窗口。然而，目前许多例子都存在局限性，主要与酶和光催化剂之间的不兼容性有关。此外，光照下活性自由基的形成以及在所需添加剂存在下催化活性的丧失是常见的现象。正如这篇综述中所概述的，主要问题是如何克服利用光驱动（化）酶转化目前所面临的挑战。首先，我们强调了光生物催化中的一般概念，然后给出了各种光化学酶（PCE）级联的例子，进一步总结了目前 PCE 级联的合成实例，并讨论了解决这些限制的策略。
